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Jena Bioscience News Blog

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May 16, 2024

Now available: High concentration labeled nucleotides for efficient DNA and RNA Labeling

Nucleotides & Nucleosides Probes & Epigenetics Read more...

Cy3-,Cy5- and Biotin-labeled nucleotides with increased concentration have now been added to our catalog. Check out our portfolio here!

read more

May 15, 2024

GC-rich DNA regions: Enhance amplification & sequencing resolution

Nucleotides & Nucleosides Probes & Epigenetics

In addition to 7-Deaza-dGTP and
dITP, we now offer N4-Methyl-dCTP that can be used as dCTP substitute.

Feb 19, 2024

Novel fluorescent probes with improved stability and affinity for Gαi1 protein

Nucleotides & Nucleosides Read more...

A new generation of GTP analogs labeled with 5-FAM show improved hydrolytic stability and binding affinity for Gαi1 protein compared to commonly used MANT and BODIPY FL GTPγS. Read more...

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Jul 12, 2023

Stable Isotope labeled Nucleosides & Nucleotides

Nucleotides & Nucleosides RNA Technologies

We now offer a selection of 13C, 15N, 19F and 2H labeled RNA phosphoramidites and NTPs.

Mar 23, 2023

Efficient RNA Labeling with abberior® STAR dyes

Nucleotides & Nucleosides Probes & Epigenetics RNA Technologies Read more...

Efficient preparation of abberior® STAR dye-labeled RNA is now easily achievable via in vitro transcription. Read more...

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Mar 18, 2023

Now available: abberior® dye-labeled nucleotides

Nucleotides & Nucleosides Probes & Epigenetics RNA Technologies

Select one of our catalog products
UTP labeled with abberior® STAR 580
UTP labeled with abberior® STAR RED
dUTP labeled with abberior® STAR 580
dUTP labeled with abberior® STAR RED
or contact us if you are interested in a different abberior® dye-nucleotide conjugate.

Jan 25, 2023

N1-Methylpseudouridine: Increase mRNA vaccine effectiveness

Nucleotides & Nucleosides RNA Technologies Read more...

Replacement of Uridine with N1-Methylpseudouridine has been utilized in the COVID-19 mRNA vaccines developed by both Pfizer-BioNTech and Moderna.

Research suggests that incorporation of N1-Methylpseudouridine increases mRNA vaccine effectiveness through enhanced protein expression combined with low immunogenicity. Read more...

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Nov 22, 2022

mRNA quality control: Easy detection of dsRNA impurities

RNA Technologies Nucleotides & Nucleosides Easy detection of dsRNA impurities

Double-stranded RNA (dsRNA) is a major impurity of therapeutic mRNA produced by in vitro transcription. Impurity levels of this transcriptional by-product need to be tightly monitored in mRNA production lots to ensure efficient mRNA expression and to reduce the risk of undesired high immunogenicity.

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May 17, 2022

Fishing for Glyco-Proteins

Nucleotides & Nucleosides

Identify and isolate O-GlcNAc modifications on glyco-proteins using UDP-GalNAz! Read more...

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Feb 24, 2022

Extended Cap Analoga portfolio

Nucleotides & Nucleosides RNA Technologies

GP3A and m7GP3A are now available for in vitro transcription experiments with A-initiating T7 class II phi 2.5 promotor-containing DNA templates.

Jan 12, 2022

Fission impossible: Non-hydrolyzable nucleotide analogs

Nucleotides & Nucleosides Read more...

Non-hydrolyzable nucleotides are essential tools for biochemical studies. More than 80 new analogs are now available as catalog products. Read more...

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Nov 18, 2021

One-step 3'-End RNA Labeling with AF (Alexa Fluor®)-Dyes

Nucleotides & Nucleosides Probes & Epigenetics

One-step labeling of short 3'-End AF (Alexa Fluor®)-Dye modified RNA is now easily achievable.

read more

Sep 21, 2021

Phosphorothioate-modified (m)RNA: Improved stability & enhanced translation efficiency

Nucleotides & Nucleosides RNA Technologies Read more...

Phosphorothioate-modified (m)RNA is conveniently prepared by enzymatic incorporation of NTPαS thus generating (m)RNA with improved stability and translation efficiency profile. Read more...

read more

Jan 12, 2021

Selective mitochondrial DNA staining: PdG

Nucleotides & Nucleosides Probes & Epigenetics Read more...

Visualize cellular mtDNA clearly and selectively with PdG (6-O-propynyl-dG) and see the advantages over 5-ethynyl-dU! Read more...

read more

Sep 09, 2020

RNA-Protein Photocrosslinking: Site- and sequence-specific Tracking

Nucleotides & Nucleosides RNA Technologies Click here and see how it works

Explore the advantages of using 4-Thio-uridine containing products to identify RNA-protein interactions both in cells and in vitro!

read more

May 14, 2020

Optimized RNA labeling: Paired metabolic reporters

Nucleotides & Nucleosides Click Chemistry See how it works!

Explore the advantages of our new vinyl-modified nucleosides, which offer in combination with our labeled Pyrimidyl tetrazines the ability as high efficient metabolic reporters in RNA expression profiling!

read more

Mar 12, 2020

Explore the ATP binding proteome!

Nucleotides & Nucleosides Probes & Epigenetics Learn more!

Explore the ATP binding proteome with our new Acyl-ATP probes, ATP-acetyl-hex-Biotin and ATP-acetyl-Desthiobiotin!

read more

Jan 08, 2020

12 New non-hydrolyzable nucleotides available!

Nucleotides & Nucleosides Learn more!

We have expanded our portfolio of non-hydrolyzable nucleotides with 12 new compounds to study protein-protein interactions, structure and dynamics of protein-nucleotide complexes, and NTPase kinetics. Find more information here!

read more

Oct 24, 2019

cGAMPs: The Second Messengers you need

Nucleotides & Nucleosides Join the exciting field of cyclic dinucleotide signaling and expand your molecular toolbox!

cGAMPs are cyclic dinucleotides (CDNs) consisting of a 12-or-13-membered ring scaffold and two ribonucleotides. To date, two cGAMPs have been discovered in nature - 2‘,3‘-cGAMP and 3‘,3‘-cGAMP. Join the exciting field of cyclic dinucleotide signaling and expand your molecular toolbox!

read more

Aug 12, 2019

Biotin-16-ddUTP is now available for:

Nucleotides & Nucleosides

  • 3'-end labeling
  • MALDI-TOF MS-based SNP typing assay
  • standard nick translation reaction for tumor DNA labelling during comparative genomic hybridization
  • Biotinylation of in vitro transcribed tmRNA during surface plasmon resonance (SPR) technique

Jul 05, 2019

Available again!

Nucleotides & Nucleosides Click Chemistry

2-Ethynyl-Adenosine-NAD+ (2-EA-NAD+), a clickable probe for the detection of protein ADP-ribosylation, is now back in our catalog.

Jun 13, 2019

Swiss Army Knives for NTPase Analysis

Nucleotides & Nucleosides See how it works!

BODIPY® FL NTPs are multipurpose tools for

  • Nucleotide binding studies on Gα, Ras, FHIT and RNAse L proteins
  • GTPase activity assays
  • Activity-based covalent labeling of bacterial two-component systems
See how it works!

read more

Feb 21, 2019

Fission Impossible: Non-hydrolyzable nucleotide analogs

Nucleotides & Nucleosides Non-Hydrolyzable Nucleotides

To study:

  • protein-protein interactions
  • structure and dynamics of protein-nucleotide-complexes
  • NTPase kinetics
Learn more!

read more

Jan 18, 2019

Shining a Spotlight on Nucleotide-Protein Interactions

Nucleotides & Nucleosides

Fluorescent nucleotide conjugates are analytical tools with exceptional versatility. By covering a plethora of fluorescence-based techniques they are applied as drug screening probes, in cytoskeletal imaging and in nucleotide-protein interaction studies. Learn more!

read more

Nov 30, 2018

LNA-NTPs

Nucleotides & Nucleosides

LNA-ATP, LNA-GTP, LNA-CTP and LNA-UTP for DNA and RNA incorporation studies are now available.

Oct 30, 2018

Nucleotide Chemotherapeutics – A Success Story Goes On!

Nucleotides & Nucleosides Tenofovir

Antiviral and Cytostatic Nucleotide Analogs to

  • Study pharmacology
  • Elucidate metabolic pathways
  • Improve the potency
Check out our range of nucleotide chemotherapeutic derivatives!

read more

Sep 24, 2018

4-Seleno-dTTP: NGS-based mapping of m6A-modified RNA sites

Nucleotides & Nucleosides How it works

4SedTTP permits the identification of methylated adenosines

  • at single nucleotide resolution
  • without antibodies
  • in an NGS-based approach
How it works:

read more

Sep 12, 2018

4-Selenothymidine-5'-triphosphate

Nucleotides & Nucleosides

4SedTTP for precise antibody-independent m6A identification is now available.

Aug 31, 2018

Nucleotides & qPCR: Easy online Search

General Nucleotides & Nucleosides Click Chemistry Molecular Biology Probes & Epigenetics Nucleotides & qPCR: Easy online Search

Looking for nucleotides based on their structure or for a specific application?
Want to find the most suitable qPCR mix for your assay?

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Jul 03, 2018

dNTP Guide – High Performance Nucleotides

Nucleotides & Nucleosides Molecular Biology

Because nucleotides don't get better than this. Click here!

Jun 21, 2018

New in Click Chemistry: 2'-Azido-2'-dATP

Nucleotides & Nucleosides Click Chemistry

We added 2'-Azido-2'-dATP to our Click Chemistry section. For more details please click here.

Jun 04, 2018

Di-Adenosine Polyphosphates: Bacterial Signaling Molecules

Nucleotides & Nucleosides

The mode of ApnA function in bacterial signaling is awaiting its elucidation. Click to see what our compounds can contribute!

read more

May 16, 2018

Why are you still using radioactively labeled Probes?

Probes & Epigenetics Nucleotides & Nucleosides Discover the good news!

If you’re running experiments like Northern and Southern blots, or EMSA, you’re probably using radioactively labeled probes, right?
There’s good news and bad news.
The bad news is that radioactively labeled probes have a limited half-life and require special laboratory equipment...
DISCOVER THE GOOD NEWS!

read more

May 09, 2018

New: 3' End Oligonucleotide Labeling Kits

Probes & Epigenetics Nucleotides & Nucleosides

3' End Oligonucleotide Labeling Kits for preparation of Biotin- or Digoxigenin-labeled ssDNA/oligonucleotide probes are now available.

May 08, 2018

High Concentration Biotin-11-UTP

Nucleotides & Nucleosides

We now offer 75 mM Biotin-11-UTP in addition to our standard 10 mM Biotin-11-UTP solution.

Apr 18, 2018

FSBA and FSBG: Universal Traps for Triphosphate-Cleaving Enzymes

Nucleotides & Nucleosides

Probing ATPases, G-Proteins, Kinases, and Polymerases with Sulfonyl Fluoride Nucleosides – See how it can help your research!

read more

Apr 12, 2018

Biotin-14-dATP and -dCTP for Hi-C Experiments

Nucleotides & Nucleosides

Hi-C experiments allow analyses of spatial genome organization. Adjacent genome regions are tagged by enzymatic biotinylation using Biotin-14-dATP or Biotin-14-dCTP and subsequently identified by (next generation) sequencing.

read more

Feb 27, 2018

c-di-AMP – The Messenger You Can't Ignore

Nucleotides & Nucleosides

Research on bacterial second messengers has recently experienced tremendous progress, and cyclic di-AMP (c-di-AMP) is one of the rising stars.

read more

Feb 16, 2018

New DNA/RNA labeling nucleotides

Nucleotides & Nucleosides Probes & Epigenetics

We now offer Biotin-14-dCTP, Biotin-11-ATP and dUTP-XX-ATTO-425 for enzymatic DNA/RNA labeling.
Nucleotide Selector for DNA/RNA Labeling

Jan 16, 2018

Now available: c-di-AMP

Nucleotides & Nucleosides

cyclic-di-AMP - The pleiotropic bacterial second messenger now adds to our cyclic-di-Nucleotide portfolio.