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Jan 12, 2021

Selective mitochondrial DNA staining: PdG

Nucleotides & Nucleosides Probes & Epigenetics Read more...

Visualize cellular mtDNA clearly and selectively with PdG (6-O-propynyl-dG) and see the advantages over 5-ethynyl-dU! Read more...

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Sep 09, 2020

RNA-Protein Photocrosslinking: Site- and sequence-specific Tracking

Nucleotides & Nucleosides RNA Technologies Click here and see how it works

Explore the advantages of using 4-Thio-uridine containing products to identify RNA-protein interactions both in cells and in vitro!

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May 14, 2020

Optimized RNA labeling: Paired metabolic reporters

Nucleotides & Nucleosides Click Chemistry See how it works!

Explore the advantages of our new vinyl-modified nucleosides, which offer in combination with our labeled Pyrimidyl tetrazines the ability as high efficient metabolic reporters in RNA expression profiling!

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Mar 12, 2020

Explore the ATP binding proteome!

Nucleotides & Nucleosides Probes & Epigenetics Learn more!

Explore the ATP binding proteome with our new Acyl-ATP probes, ATP-acetyl-hex-Biotin and ATP-acetyl-Desthiobiotin!

read more

Jan 08, 2020

12 New non-hydrolyzable nucleotides available!

Nucleotides & Nucleosides Learn more!

We have expanded our portfolio of non-hydrolyzable nucleotides with 12 new compounds to study protein-protein interactions, structure and dynamics of protein-nucleotide complexes, and NTPase kinetics. Find more information here!

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Oct 24, 2019

cGAMPs: The Second Messengers you need

Nucleotides & Nucleosides Join the exciting field of cyclic dinucleotide signaling and expand your molecular toolbox!

cGAMPs are cyclic dinucleotides (CDNs) consisting of a 12-or-13-membered ring scaffold and two ribonucleotides. To date, two cGAMPs have been discovered in nature - 2‘,3‘-cGAMP and 3‘,3‘-cGAMP. Join the exciting field of cyclic dinucleotide signaling and expand your molecular toolbox!

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Aug 12, 2019

Biotin-16-ddUTP is now available for:

Nucleotides & Nucleosides

  • 3'-end labeling
  • MALDI-TOF MS-based SNP typing assay
  • standard nick translation reaction for tumor DNA labelling during comparative genomic hybridization
  • Biotinylation of in vitro transcribed tmRNA during surface plasmon resonance (SPR) technique

Jul 05, 2019

Available again!

Nucleotides & Nucleosides Click Chemistry

2-Ethynyl-Adenosine-NAD+ (2-EA-NAD+), a clickable probe for the detection of protein ADP-ribosylation, is now back in our catalog.

Jun 13, 2019

Swiss Army Knives for NTPase Analysis

Nucleotides & Nucleosides See how it works!

BODIPY® FL NTPs are multipurpose tools for

  • Nucleotide binding studies on Gα, Ras, FHIT and RNAse L proteins
  • GTPase activity assays
  • Activity-based covalent labeling of bacterial two-component systems
See how it works!

read more

Feb 21, 2019

Fission Impossible: Non-hydrolyzable nucleotide analogs

Nucleotides & Nucleosides Non-Hydrolyzable Nucleotides

To study:

  • protein-protein interactions
  • structure and dynamics of protein-nucleotide-complexes
  • NTPase kinetics
Learn more!

read more

Jan 18, 2019

Shining a Spotlight on Nucleotide-Protein Interactions

Nucleotides & Nucleosides

Fluorescent nucleotide conjugates are analytical tools with exceptional versatility. By covering a plethora of fluorescence-based techniques they are applied as drug screening probes, in cytoskeletal imaging and in nucleotide-protein interaction studies. Learn more!

read more

Nov 30, 2018

LNA-NTPs

Nucleotides & Nucleosides

LNA-ATP, LNA-GTP, LNA-CTP and LNA-UTP for DNA and RNA incorporation studies are now available.

Oct 30, 2018

Nucleotide Chemotherapeutics – A Success Story Goes On!

Nucleotides & Nucleosides Tenofovir

Antiviral and Cytostatic Nucleotide Analogs to

  • Study pharmacology
  • Elucidate metabolic pathways
  • Improve the potency
Check out our range of nucleotide chemotherapeutic derivatives!

read more

Sep 24, 2018

4-Seleno-dTTP: NGS-based mapping of m6A-modified RNA sites

Nucleotides & Nucleosides How it works

4SedTTP permits the identification of methylated adenosines

  • at single nucleotide resolution
  • without antibodies
  • in an NGS-based approach
How it works:

read more

Sep 12, 2018

4-Selenothymidine-5'-triphosphate

Nucleotides & Nucleosides

4SedTTP for precise antibody-independent m6A identification is now available.

Aug 31, 2018

Nucleotides & qPCR: Easy online Search

General Nucleotides & Nucleosides Click Chemistry Molecular Biology Probes & Epigenetics Nucleotides & qPCR: Easy online Search

Looking for nucleotides based on their structure or for a specific application?
Want to find the most suitable qPCR mix for your assay?

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Jul 03, 2018

dNTP Guide – High Performance Nucleotides

Nucleotides & Nucleosides Molecular Biology

Because nucleotides don't get better than this. Click here!

Jun 21, 2018

New in Click Chemistry: 2'-Azido-2'-dATP

Nucleotides & Nucleosides Click Chemistry

We added 2'-Azido-2'-dATP to our Click Chemistry section. For more details please click here.

Jun 04, 2018

Di-Adenosine Polyphosphates: Bacterial Signaling Molecules

Nucleotides & Nucleosides

The mode of ApnA function in bacterial signaling is awaiting its elucidation. Click to see what our compounds can contribute!

read more

May 16, 2018

Why are you still using radioactively labeled Probes?

Probes & Epigenetics Nucleotides & Nucleosides Discover the good news!

If you’re running experiments like Northern and Southern blots, or EMSA, you’re probably using radioactively labeled probes, right?
There’s good news and bad news.
The bad news is that radioactively labeled probes have a limited half-life and require special laboratory equipment...
DISCOVER THE GOOD NEWS!

read more

May 09, 2018

New: 3' End Oligonucleotide Labeling Kits

Probes & Epigenetics Nucleotides & Nucleosides

3' End Oligonucleotide Labeling Kits for preparation of Biotin- or Digoxigenin-labeled ssDNA/oligonucleotide probes are now available.

May 08, 2018

High Concentration Biotin-11-UTP

Nucleotides & Nucleosides

We now offer 75 mM Biotin-11-UTP in addition to our standard 10 mM Biotin-11-UTP solution.

Apr 18, 2018

FSBA and FSBG: Universal Traps for Triphosphate-Cleaving Enzymes

Nucleotides & Nucleosides

Probing ATPases, G-Proteins, Kinases, and Polymerases with Sulfonyl Fluoride Nucleosides – See how it can help your research!

read more

Apr 12, 2018

Biotin-14-dATP and -dCTP for Hi-C Experiments

Nucleotides & Nucleosides

Hi-C experiments allow analyses of spatial genome organization. Adjacent genome regions are tagged by enzymatic biotinylation using Biotin-14-dATP or Biotin-14-dCTP and subsequently identified by (next generation) sequencing.

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Mar 01, 2018

Catch and Release of Diols with Boronic Acid Agarose

Nucleotides & Nucleosides Proteins

The immobilization of boronic acids on solid support offers a versatile approach to isolate a diverse set of biomolecular diols from complex mixtures. Learn more...

Feb 27, 2018

c-di-AMP – The Messenger You Can't Ignore

Nucleotides & Nucleosides

Research on bacterial second messengers has recently experienced tremendous progress, and cyclic di-AMP (c-di-AMP) is one of the rising stars.

read more

Feb 16, 2018

New DNA/RNA labeling nucleotides

Nucleotides & Nucleosides Probes & Epigenetics

We now offer Biotin-14-dCTP, Biotin-11-ATP and dUTP-XX-ATTO-425 for enzymatic DNA/RNA labeling.
Nucleotide Selector for DNA/RNA Labeling

Jan 16, 2018

Now available: c-di-AMP

Nucleotides & Nucleosides

cyclic-di-AMP - The pleiotropic bacterial second messenger now adds to our cyclic-di-Nucleotide portfolio.