Jul 04, 2025
We extended our portfolio of RNA Cap Analogs: m7GP32'-OmA
Jun 24, 2025
Double-stranded RNA (dsRNA) is a critical by-product of wildtype T7 RNA Polymerase-based in vitro transcription. It needs to be minimized in final RNA preparations to reduce the risk of undesired immune responses.
May 15, 2025
Double-stranded RNA (dsRNA) antibodies are efficient tools for the detection of dsRNA in various samples.
Mar 18, 2025
We now offer Desthiobiotin-modified NTPs and Labeling Kits for efficient enzymatic preparation of Desthiobiotinylated long non-coding RNA (lncRNA) probes. Read more...
Jul 31, 2024
Katalin Karikó‘s and Drew Weissman‘s Nobel Prize-winning concept of nucleoside base modifications as basis for the development of effective mRNA vaccines has been successfully applied to self-amplifying RNA (saRNA). Read more...
Nov 02, 2023
5’-capping and nucleoside base modifications significantly increase translation efficiency while reducing immunogenicity of synthetic mRNA. Read more...
Jul 12, 2023
We now offer a selection of 13C, 15N, 19F and 2H labeled RNA phosphoramidites and NTPs.
Mar 23, 2023
Efficient preparation of abberior® STAR dye-labeled RNA is now easily achievable via in vitro transcription. Read more...
Mar 18, 2023
Select one of our catalog products
UTP labeled with abberior® STAR RED
dUTP labeled with abberior® STAR RED
or contact us if you are interested in a different abberior® dye-nucleotide conjugate.
Jan 25, 2023
Replacement of Uridine with N1-Methylpseudouridine has been utilized in the COVID-19 mRNA vaccines developed by both Pfizer-BioNTech and Moderna.
Research suggests that incorporation of N1-Methylpseudouridine increases mRNA vaccine effectiveness through enhanced protein expression combined with low immunogenicity. Read more...
Nov 22, 2022
Double-stranded RNA (dsRNA) is a major impurity of therapeutic mRNA produced by in vitro transcription. Impurity levels of this transcriptional by-product need to be tightly monitored in mRNA production lots to ensure efficient mRNA expression and to reduce the risk of undesired high immunogenicity.
Apr 14, 2022
We extended our portfolio of fluorescent nucleotides for in vitro transcription experiments with AZDye-labeled CTPs:
CTP-PEG5-AZDye 488
CTP-PEG5-AZDye 555
CTP-PEG5-AZDye 594
CTP-PEG5-AZDye 647
Feb 24, 2022
GP3A and m7GP3A are now available for in vitro transcription experiments with A-initiating T7 class II phi 2.5 promotor-containing DNA templates.
Sep 21, 2021
Phosphorothioate-modified (m)RNA is conveniently prepared by enzymatic incorporation of NTPαS thus generating (m)RNA with improved stability and translation efficiency profile. Read more...
Dec 08, 2020
RNA synthesis kits with a T7 RNA polymerase triple mutant are now available for efficient 2'F-modified Aptamers preparation:
2'F-dUTP-based, 2'F-dCTP-based, 2'F-dGTP-based, 2'F-dATP-based
Nov 03, 2020
Double-stranded RNA (dsRNA) is a key molecule in RNA interference (RNAi)-mediated gene silencing at the mRNA level. Large amounts of dsRNA can be efficiently synthesized via in vitro transcription.
Oct 06, 2020
Structural investigations of RNA require a homogenous RNA preparation. Learn how to reduce in vitro transcription-caused 5' heterogeneity!
Sep 09, 2020
Explore the advantages of using 4-Thio-uridine containing products to identify RNA-protein interactions both in cells and in vitro!
Jun 16, 2020
HighYield T7 RNAi Kit is now available for the production of dsRNA >200 bp that can subsequently be used for RNA interference (RNAi) applications.
Jun 11, 2020
Poly (A) carrier RNA facilitates quantitative purification of low RNA amounts. Read more...
Jun 09, 2020
T7 RNA Polymerase (HC) is now available for set-up and optimization of individual high yield in vitro transcription reactions.
Jun 06, 2020
We now offer Poly(A) carrier RNA for quantitative purification of RNA and DNA.
Apr 08, 2020
Efficient preparation of AZDye-labeled RNA is now easily achievable via in vitro transcription. Read more...
Apr 03, 2020
Anti-dsRNA monoclonal antibodies are efficient tools for the detection of dsRNA both in cell culture and FFPE samples. Read more...
Mar 26, 2020
We now offer the Anti-dsRNA monoclonal antibodies J2, K1 and K2.
Mar 20, 2020
Efficient AZDye RNA labeling is now feasible with our HighYield T7 AZDye 488-, HighYield T7 AZDye 555-, HighYield T7 AZDye 594- and HighYield T7 AZDye 647-RNA Labeling Kits.
Feb 24, 2020
We now offer a HighYield RNA Synthesis Kit based on a modified T7 RNA Polymerase that has been associated with decreased abortive transcription, increased transcript 5' homogeneity and increased 5' incorporation efficiency of GTP analogs.
Feb 06, 2020
5’-capping and epigenetic nucleotide modifications are critical for efficient translation and reduced immunogenicity of synthetic mRNA. The classic combination of modifications consists of ARCA, 5-methylcytidine and pseudouridine. Promising extensions of the mRNA modification toolbox are available.
Jan 24, 2020
We now offer ATTO680 NT Labeling kit for the preparation of ATTO680-labeled DNA probes via nick translation.
Nov 05, 2019
Current near-IR fluorescent RNA probes use dye-labeled nucleotides with only moderate sensitivity. Use copper-free CLICK labeling for increased sensitivity. Learn more here!
Oct 01, 2019
CRISPR/Cas systems are the most flexible and efficient site-directed gene targeting tools currently available. Learn more!
Sep 30, 2019
We now offer a convenient and efficient HighYield T7 sgRNA Synthesis Kit (SpCas9) for cloning-free preparation of SpCas9-specific sgRNA. Individual (s)gRNA-encoding T7 DNA templates (e.g with a different Cas9 scaffold or for different Cas endonucleases) can efficiently be in vitro transcribed with the HighYield T7 RNA Synthesis Kit.
Sep 11, 2019
We now offer the RNA-modifying enzyme Yeast Poly(A) Polymerase.
Aug 19, 2019
We now offer HighYield kits for synthesis of ARCA-capped and/or 5-methylcytosine & pseudouridine-modified (m)RNA.
Jun 25, 2019
HighYield T7 RNA Labeling Kits for preparation of Digoxigenin, Biotin and fluorescent RNA probes are now available. The single nucleotide format offers maximum optimization flexibility.
Jun 07, 2019
Now available! Our HighYield T7 RNA Synthesis Kit is designed for the efficient production of unmodified and modified RNA.
Mar 07, 2019
Looking for products to support your RNA research? Then have a look here!
Feb 18, 2019
Looking for products to support your RNA research? Have a look at our new RNA Technologies section.
Our product portfolio will constantly be extended. Want to stay updated?
Sign up for our RNATech newsletter or contact us at rnatech@jenabioscience.com!
