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RNA Technologies

Ribonucleic acids (RNAs) are essential for transfer of genetic information and cell regulation. About 1-2% of the transcribed genome (transcriptome) consists of protein-coding messenger RNAs (mRNAs). The vast majority however, are non-coding RNAs (ncRNAs) of various length and function1-5: protein synthesis-related housekeeping RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA)) and regulatory RNAs (> 200 nt: long non-coding RNA (lncRNA), < 200 nt: e.g. micro RNA (miRNA), small interfering RNA (siRNA) or PIWI-interacting RNA (piRNA)). Circular RNAs (circRNAs) have initially been categorized as non-coding RNAs4 but contain protein-coding functions5 as well.

 
 
 
 
 

You have interesting reagents and want to commercialize them? Please contact us at rnatech@jenabioscience.com for details!

Selected References

[1] Cech et al. (2014) The noncoding RNA revolution – trashing old rules to forge new ones. Cell 157:17.
[2] Morris et al. (2014) The rise of regulatory RNA. Nature Reviews Genetics 15:423.
[3] Uszczynska-Ratajczak et al. (2018) Towards a complete map of the human long non-coding RNA transcriptome. Nature Reviews Genetics 19:423.
[4] Wiluz et al. (2013) A circuitous route to noncoding RNA. Science 340 (6131):440.
[5] Pamudurti et al. (2017) Translation of circRNAs. Molecular Cell 66:9.