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cGAMPs: The Second Messengers you need

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cGAMPs are cyclic dinucleotides (CDNs) consisting of a 12-or-13-membered ring scaffold and two ribonucleotides. To date, two cGAMPs have been discovered in nature - 2‘,3‘-cGAMP[1] and 3‘,3‘-cGAMP[2].

2,3-cGAMP
→ cyclized from ATP and GTP by a cyclic GMP-AMP synthase
→ identified as a novel second messenger in metazoan[3]
→ triggers innate immune response in mammalian cells[4,5]
3,3-cGAMP
→ synthesized from ATP and GTP by a dinucleotide cyclase
→ crucial signaling molecule for regulating bacterial virulence[2]
→ triggers innate immune response in mammalian cells[6]

The important physiological roles played by cyclic dinucleotides sparked interest in:

  • how nucleotide-based second messengers regulate physiological processes
  • new research directed towards interruption of cyclic dinucleotide signaling
  • potential adjuvants for vaccine development
Compound Cat. No. Amount Price
2',3'-cGAMP NU-249S 1 µmol 96,43 €
NU-249L 5 x 1 µmol 385,70 €
3',3'-cGAMP NU-986S 1 µmol 96,43 €
NU-986L 5 x 1 µmol 385,70 €
More Bacterial Second Messengers can be found here!

Dr. Thomas Waldbach

2‘,3‘-cGAMP and 3‘,3‘-cGAMP in stock at Jena Bioscience. Please email Thomas for other cyclic dinucleotide pairs or with technical questions!

Selected References:

[1] Ablasser et al. (2013) cGAS produces a 2‘-5‘-linked cyclic dinucleotide second messenger that activates STING. Nature 498:380.
[2] Davies et al. (2012) Coordinated regulation of accessory genetic elements produces cyclic dinucleotides for V. cholerae virulence. Cell 149:358.
[3] Gao et al. (2013) Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153 (5):1094.
[4] Tao et al. (2016) cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling. IUBMB Life 68 (11):858.
[5] Opoku-Temeng et al. (2016) Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules. Chem. Commun. 52:9327.
[6] Ren et al. (2015) Structural basis for molecular discrimination by a 3‘,3‘-cGAMP sensing riboswitch. Cell Reports 11:1.