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Fission impossible: Non-hydrolyzable nucleotide analogs

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Crucial cellular processes such as transport, motion and division are orchestrated by a highly diverse set of regulatory phosphatases. Non-hydrolyzable analogs of nucleotides trap these enzymes in their various biologically relevant states and are thus essential tools for biochemical studies.

More than two decades of experience in the preparation of non-hydrolyzable nucleotides led to a comprehensive non-hydrolyzable nucleotide portfolio (Figure 1) ideally suited for

  • identification of protein-protein interactions and enzyme substrates
  • elucidation of structure and dynamics of protein-nucleotide-complexes
  • kinetic analysis of nucleotide exchange reactions on NTPase
Non-Hydrolyzable Nucleotides

Scheme 1: More than 80 non-hydrolyzable nucleotides are available as catalog products.

Questions or inquiries?

Dr. Barbara Zschoernig

Contact us if you do not find the nucleotide you are looking for!