Single particle electron cryo-microscopy (cryo-EM) is a powerful technique to determine the structures of protein complexes down to atomic resolution. The sample is applied onto a holey carbon film and is then flash-frozen in liquid ethane. C-flat™ holey carbon films are superflat sample supports providing flat and even amorphous ice. And: they are in stock for immediate delivery! Learn more...
Northern Blots: 0.05 fmol detection limit with near-IR RNA Probes
Current near-IR fluorescent RNA probes use dye-labeled nucleotides with only moderate sensitivity. Use copper-free CLICK labeling for increased sensitivity. Learn more here!
Oct 24, 2019
cGAMPs: The Second Messengers you need
cGAMPs are cyclic dinucleotides (CDNs) consisting of a 12-or-13-membered ring scaffold and two ribonucleotides. To date, two cGAMPs have been discovered in nature - 2‘,3‘-cGAMP and 3‘,3‘-cGAMP. Join the exciting field of cyclic dinucleotide signaling and expand your molecular toolbox!