Ribavirin-triphosphate
For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C8H15N4O14P3 (free acid)
Molecular Weight: 484.14 g/mol (free acid)
Exact Mass: 483.98 g/mol (free acid)
CAS#: 63142-71-2
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 230 nm, ε 3.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Selected References:
Kiso et al. (2010) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. USA. 107 (2):882.
Maag et al. (2001) Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276 (49):46094.
Lanford et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75 (17):8074.
Crotty et al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6 (12):1375.
Ulrich et al. (2000) Towards the engineering of an orthogonal protein kinase/nucleotide triphosphate pair. Tetrahedron 56 (48):9495.
Hong et al. (1999) Direct antiviral activity of ribavirin: Hepatitis C virus NS5B polymerase incorporates ribavirin triphosphate into nascent RNA products. Hepatology 30 (4):773 Part 2 Suppl. S.
Jarvis et al. (1998) Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)- nucleoside transporters. Brit. J. Pharmacol. 123 (8):1587.
Hosoya et al. (1993) Comparative inhibitory effects of various nucleoside and nonnucleoside analogs on replication of influenza-virus type-A and type-B in-vitro and inovo. J. Infect. Dis. 168 (3):641.
Wray et al. (1985) Effect of ribavirin triphosphate on primer generation and elongation during influenza-virus transcription invitro. Antivir. Res. 5 (1):39.
Eriksson et al. (1977) Inhibition of influenza-virus ribonucleic-acid polymerase by ribavirin triphosphate. Antimicrob. Agents Ch. 11 (6):946.
| Cat. No. | Amount | Price |
|---|---|---|
| NU-1105S | 20 μl (10 mM) | 165,40 € |
| NU-1105L | 5 x 20 μl (10 mM) | 484,60 € |
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Scientific citations for Jena Bioscience nu-1105
13 scientific citations and 1 citation images found by Bioz.
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Structure of Crimean-Congo haemorrhagic fever virus RNA polymerase.
Nature Microbiology, 2026-06-05 · PMID:41991608
Abstract: Crimean-Congo haemorrhagic fever virus (CCHFV) is a highly pathogenic member of the Nairoviridae and causes severe disease with high fatality rates. Currently, there are no approved antivirals for CCHFV, but resolving the structure of its RNA-dependent RNA polymerase, termed L protein, could help drug development. Here we report cryogenic electron microscopy structures of the CCHFV L protein in both apo and RNA-bound states at 2.62 Å and 2.53 Å, respectively
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Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates.
The Journal of Biological Chemistry, 2024-09-09 · PMID:39260691
.. Fisher Scientific (Waltham, Massachusetts, U.S.).NTPs were purchased from Thermo Fisher Scientific (Waltham, Massachusetts, U.S.).. 8oA, 8oG and
RIB triphosphates were purchased fromJena Bioscience (Jena, Germany).. FOR and PYR nucleosides were purchased from Merck (Darmstadt, Germany) and triphosphorylated in-house (see .. -
Characterizing single-molecule dynamics of viral RNA-dependent RNA polymerases with multiplexed magnetic tweezers
STAR Protocols, 2022-08-05 · DOI:10.1016/j.xpro.2022.101606
.. triphosphate , Blake Peterson lab , N/A.T1106 triphosphate , Blake Peterson lab , N/A..
Ribavirin triphosphate ,Jena Bioscience , Cat#NU-1105 L.. Superase RNase inhibitor , Thermo Fisher Scientific , Cat#AM2694.Superase RNase inhibitor , Thermo Fisher ..
