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8-Oxo-GTP

8-Hydroxy-GTP

8-Oxo-guanosine-5'-triphosphate, Sodium salt

8-Hydroxy-guanosine-5'-triphosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-1116S 50 μl (10 mM) 120,22 Add to Basket/Quote Add to Notepad
NU-1116L 5 x 50 μl (10 mM) 352,16 Add to Basket/Quote Add to Notepad
Structural formula of 8-Oxo-GTP (8-Hydroxy-GTP, 8-Oxo-guanosine-5'-triphosphate, Sodium salt)
Structural formula of 8-Oxo-GTP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C10H16N5O15P3 (free acid)

Molecular Weight: 539.18 g/mol (free acid)

Exact Mass: 538.99 g/mol (free acid)

CAS#: 21238-36-8

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 245 nm, ε 12.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Hydrolysis by arabidopsis Nudix hydrolase[1]
X-ray analysis of complex with GTP-cyclohydrolase I (GTPCH 1)[2]

Specific Ligands:

Binding to cancer-related PRUNE2[3]

Product Citations:
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.

Selected References:
[1] Yoshimura et al. (2007) AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis. Plant and Cell Physiology 48:1438.
[2] Tanaka et al. (2005) Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative. J. Biochem. (Tokyo) 138 (3):263.
[3] Iwama et al. (2011) Cancer related PRUNE 2 protein is associated with nucleotides and is highly expressed in mature nerve tissues. J. Molecular Neuroscience 44:103.
Ramírez (2004) Gene of Bacillus subtilis Encodes a Functional Antimutator 8-Oxo- (dGTP/GTP)ase and Is under Dual Control of Sigma A and Sigma F RNA Polymerases. Journal of bacteriology 186 (4):1050.
Nakabeppu (2001) Molecular genetics and structural biology of human MutT homolog, MTH1. Mutat Res. 477 (1-2):59.
Kobayashi et al. (1998) Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 273 (41):26394.
Kuryavyi et al. (1989) Kinetics of inhibition of escherichia-coli RNA polymerase-catalyzed synthesis of the dinucleotide pppApU by 8-oxo-GTP and 8-BrGTP on the A1 promoter of Bacteriophage-t7 delta-d111 DNA using a limited set of substrates. Mol. Biol. 23 (3):648.