Vidarabine triphosphate, Sodium Salt
Adenine-arabinofuranoside-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H16N5O13P3 (free acid)
Molecular Weight: 507.18 g/mol (free acid)
Exact Mass: 507.00 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 259 nm, ε 15.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Isolation from marine sponge Tethya crypta
Substrate for poly(A) polymerase (gammaPAP)
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.
 Sagar et al. (2010) Antiviral lead compounds from marine sponges. Mar. Drugs. 8 (10):2619.
 Wilhelmus (2010) Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. (12):CD002898.
 Chen et al. (2008) Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues. Leuk. Res. 32 (10):1573.
Genini et al. (2000) Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J. Biol. Chem. 275 (1):29.
Ghoshal et al. (1991) Ara-ATP impairs 3'-end processing of pre-messenger-RNAs by inhibiting both cleavage and polyadenylation. Nucleic Acids Res. 19 (21):5871.
Biron et al. (1991) Selective anabolism of 6-methoxypurine arabinoside in Varicella-zoster virus-infected cells. Antimicrob. Agents Ch. 35 (10):2116.
Demiranda et al. (1991) Anabolic pathway of 6-methoxypurine arabinoside in cells infected with Varicella-zoster virus. Antimicrob. Agents Ch. 35 (10):2121.
Plunkett et al. (1981) Cellular concentrations of dATP and ara-ATP in peripheral-blood leukemic-cells (PBC) and erythrocytes (RBC) from patients treated with deoxycoformycin (DCF) or Arabinosyladenine (ara-A). P. Am. Assoc. Canc. Res. 22 (Mar):177.
Shewach et al. (1981) Relationship between ara-ATP concentration, DNA synthetic capacity (DSC) and viability in cho cells. P. Am. Assoc. Canc. Res. 22 (Mar):255.
Spater et al. (1981) Neuronal phosphatase-activities with ara-AMP and ara-ATP as substrates. J. Histochem. Cytochem. 29 (6):693.
Chanda et al. (1980) Inhibition of vesicular stomatitis-virus transcriptase invitro by phosphonoformate and ara-ATP. Virology 107 (2):562.
Dennis et al. (1980) RNA-polymerase - potent linear competitive-inhibition by D Arabinose-5-triphosphate compared to non-inhibition by 5' ara-ATP. Biochem. Bioph. Res. Co. 94 (1):205.
Shewach et al. (1979) Effect of deoxycoformycin (DCF) on the toxicity and metabolism of 9-beta-d-arabinofuranosyladenine (ara-A) and its 5'-triphosphate (ara-ATP) in cho cells. P. Am. Assoc. Canc. Res. 20 (Mar):183.
Chanda et al. (1979) Inhibition of invitro RNA-transcription of vesicular stomatitis-virus by phosphonoformate and ara-ATP. Fed. Proc. 38 (3):814.
Rose et al. (1978) Selective-inhibition of RNA polyadenylation by ara-ATP invitro - possible mechanism for anti-viral action of ara-A. Biochem. Bioph. Res. Co. 81 (4):1418.
Ortiz (1972) Inhibition of escherichia-coli adenyl-cyclase by ara ATP. Biochem. Bioph. Res. Co. 46 (4):1728.