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THPTA

Tris((1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl)amine

Cat. No. Amount Price (EUR) Buy / Note
CLK-1010-25 25 mg 88,44 Add to Basket/Quote Add to Notepad
CLK-1010-100 100 mg 142,48 Add to Basket/Quote Add to Notepad
CLK-1010-1G 1 g 431,76 Add to Basket/Quote Add to Notepad
Structural formula of THPTA (Tris((1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl)amine)
Structural formula of THPTA

For research use only!

Shipping: shipped at ambient temperature

Storage Conditions: store at 4 °C

Shelf Life: 12 months after date of delivery

Molecular Formula: C18H30N10O3

Molecular Weight: 434.50 g/mol

Exact Mass: 434.25 g/mol

CAS#: 760952-88-3

Purity: > 95 % (HPLC)

Form: off-white to grey solid

Solubility: water, DMSO, DMF, MeOH

Description:
THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Accelaration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction[1,2].

THPTA is a superior alternative to water-insoluble TBTA.

A stock solution can be prepared in ddH2O and subsequently be stored at -20°C. Avoid freeze-thaw cycles.

Presolski et al.[1] and Hong et al.[2] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.

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Product Citations:
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.

Selected References:
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153.
[2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879.