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Na-Ascorbate - click chemistry grade

L-Ascorbic acid sodium salt

Cat. No. Amount Price (EUR) Buy / Note
CLK-MI005-1G 5 x 200 mg 86,60 Add to Basket/Quote Add to Notepad

For general laboratory use.

Shipping: shipped at ambient temperature

Storage Conditions: store at ambient temperature
store dry

Shelf Life: 12 months after date of delivery

Molecular Formula: C6H7NaO6

Molecular Weight: 198.11 g/mol

CAS#: 134-03-2

Form: solid

Color: white to off-white

Solubility: water

Na-Ascorbate can be used as a reduction reagent for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC).

It catalyzes the reduction of Cu(II) sources such as CuSO4 thereby releasing catalytically reactive Cu(I) ions.

Ideally, solutions should be freshly prepared in ddH2O shortly before use. Alternatively, a stock solution can be prepared, stored at -20°C and freshly by diluted shortly before use.

Please note: Do not use solutions that appear brown. Freshly prepared, fully functional Na-Ascorbate solutions are colorless and turn brown upon oxidization thereby loosing their reduction capability.

Presolski et al.[1] and Hong et al.[2] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.

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BIOZ Product Citations:

Selected References:
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153.
[2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879.