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AP4

(Adenosine-5'-tetraphosphate)

Adenosine-5'-tetraphosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-1102S 100 μl (10 mM) 117,35 Add to Basket/Quote Add to Notepad
NU-1102L 5 x 100 μl (10 mM) 343,76 Add to Basket/Quote Add to Notepad
Structural formula of AP4 ((Adenosine-5'-tetraphosphate), Adenosine-5'-tetraphosphate, Sodium salt)
Structural formula of AP4

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C10H17N5O16P4 (free acid)

Molecular Weight: 587.16 g/mol (free acid)

Exact Mass: 586.96 g/mol (free acid)

CAS#: 1062-98-2

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 259 nm, ε 15.1 L mmol-1 cm-1 (Tris-HCl pH 7.0)

Product Citations:
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.

Selected References:
Winward et al. (2010) Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch? Int. J. Biochem. Cell. Biol. 42 (7):1174.
Safrany et al. (2007) Characterisation of a bis (5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster. Int. J. Biochem. Cell Biol. 39 (5):943.
Chang et al. (2005) Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase. J. Biol. Chem. 280 (12):11513.
Stitt et al. (2005) Catalytic Cooperativity among Subunits of Escherichia coli Transcription Termination Factor Rho. J. Biol. Chem. 280 (14):13292.
Abdelghany et al. (2001) Cloning, characterisation and crystallisation of a diadenosine 5',5'''-P-1,P-4-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. BBA-Protein Struct. M. 1550 (1):27.
Sun et al. (2001) Folate-binding triggers the activation of folylpolyglutamate synthetase. J. Mol. Biol. 310 (5):1067.
Gomez-Villafuertes et al. (2000) Adenosine 5'-tetraphosphate (Ap (4)), a new agonist on rat midbrain synaptic terminal P2 receptors. Neuropharmacology 39 (12):2381.
Bouhss et al. (1999) Formation of adenosine 5'-tetraphosphate from the acyl phosphate intermediate: a difference between the MurC and
MurD synthetases of Escherichia coli. FEBS Lett. 453 (1-2):15.
Cartwright et al. (1999) The Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5',5'''-P-1,P-6-hexaphosphate (Ap (6)A) hydrolase member of the MutT motif (nudix hydrolase) family. J. Biol. Chem. 274 (13):8604.
Pintor et al. (1998) Effect of adenosine 5'-tetraphosphate on P2x receptors in rat brain synaptic terminals. J. Neurochem. 71:S25 Suppl.1.
Kulakovskaya et al. (1997) Adenosine-5'-tetraphosphate and guanosine-5'-tetraphosphate: New substrates of the cytosolic exopolyphosphatase of the yeast Saccharomyces cerevisiae. Biochemistry-Moscow 62 (9):1051.
Mukai (1992) Alternative synthesis of Guanosine 5'-diphosphate 3'-diphosphate and Adenosine 5'-diphosphate 3'-diphosphate from adenosine 5'-tetraphosphate by Streptomyces ATP nucleotide 3'-Pyrophosphokinase catalysis. Biosci. Biotech. Bioch. 56 (11):1876.
Ostas et al. (1990) Purification to homogeneity of rat-liver dinucleoside tetraphosphatase by affinity elution with Adenosine 5'- tetraphosphate. J. Biochem. Bioph. Meth. 21 (1):25.
Winandde et al. (1967) Interactions of Adenosine tetraphosphate with Myosin and Actomyosin. Eur. J. Biochem. 1 (1):29.
Small et al. (1966) Studies on occurrence and biosynthesis of Adenosine tetraphosphate. Biochemistry-US 5 (1):26.
Liebecq et al. (1961) Enzymatic dephosphorylation of Adenosine tetraphosphate. Nature 189 (476):661.