Guanosine-3',5'-bisphosphate

For general laboratory use.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C₁₀H₁₅N₅O₁₁P₂ (free acid)

Molecular Weight: 443.20 g/mol (free acid)

Exact Mass: 443.02 g/mol (free acid)

Purity: ≥ 95 % (HPLC)

Form: solution in water

Color: colorless to slightly yellow

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λ_max 252 nm, ε 13.7 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

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Selected References:
Kvint et al. (2000) Emergency derepression: stringency allows RNA polymerase to override negative control by an active repressor. Mol. Microbiol. 35 (2):435.
Acharya et al. (1999) The transmission of the electronic character of guanin-9-yl drives the sugar-phosphate backbone torsions in guanosine 3 ',5 '-bisphosphate. Angew. Chem. Int. Edit. 38 (24):3645.
Ishikawa et al. (1996) Crystal structure of ribonuclease T1 carboxymethylated at Glu58 in complex with 2'-GMP. Biochemistry-US 35 (25):8329.
Atgie et al. (1993) Specific decrease of mitochondrial thermogenic capacity in brown adipose-tissue of obese SHR/N-CP rats. Am. J. Physiol. 265 (6):c1674 Part 1.
Lenz et al. (1993) 3-dimensional structure of the ternary complex between Ribonuclease-T1, guanosine-3',5'-bisphosphate and inorganic-phosphate at 0.19 nm resolution. Eur. J. Biochem. 211 (1-2):311.
Lenz et al. (1991) X-ray-analysis of cubic-crystals of the complex formed between Ribonuclease-T1 and guanosine-3',5'- bisphosphate. Acta Crystallogr. B 47:521.
Plesner (1984) Guanosine 3',5'-diphosphate is found in the medium of eukaryotic cells during G1 to S-phase transition. H-S Z. Physiol. Chem. 365 (6):608.