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N6-Methyl-ATP

m6ATP

N6-Methyl-adenosine-5'-triphosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-1101S 10 μl (100 mM) 54,58 Add to Basket/Quote Add to Notepad
NU-1101L 5 x 10 μl (100 mM) 198,94 Add to Basket/Quote Add to Notepad
Structural formula of N6-Methyl-ATP (m6ATP, N6-Methyl-adenosine-5'-triphosphate, Sodium salt)
Structural formula of N6-Methyl-ATP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C11H18N5O13P3 (free acid)

Molecular Weight: 521.21 g/mol (free acid)

CAS#: 3130-39-0 (acid)

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 100 mM - 110 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 265 nm, ε 18.5 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Agonistic ligand, mainly for nucleoside receptor A1, with less affinity to A2A and A3
Nucleoside-triphosphates can be converted by different membrane-bound phosphatases into nucleosides acting as nucleoside receptor ligands. In some cases nucleoside phosphates act also directly on nucleoside receptors.

Specific Ligands:

Agonist for P2Y receptor[1] and for P2X2 purinoreceptor[2,3]

Related products: HighYield T7 RNA Synthesis Kit, #RNT-101

Selected References:
[1] Brunstock et al. (1994) Structure activity relationships for derivatives of adenosine-5'-triphosphate as agonists at P2 purinoreceptors: heterogeneity within P2X and P2Y subtypes. Drug Dev. Res. 31 (3):206.
[2] Bo et al. (1994) Comparative studies on affinities of ATP derivatives for P2X-purinoreceptors in rat urinary bladder. Br. J. Pharmacol. 112 (4):1151.
[3] He et al. (2002) Purinergic P2X (2) receptor desensitization depends on coupling between ectodomain and C-terminal domain. Molec. Pharmac. 62 (5):1187.