ara-Nucleotides
Ara-Nucleotides feature an opposite stereochemistry at the 2' carbon atom compared to ribo-nucleotides. They are incorporated into DNA by polymerases however, the DNA strand is only poorly elongated from the 3' ara-nucleotide residue and thus provides an opportunity for exonucleases to remove the ara-nucleotide.
Cytarabine (Cytosine arabinoside, ara-C) is a commonly used chemotherapy agent used mainly in the treatment of leukemia and non-Hodgkin lymphoma. It been shown to be misincorporated into DNA double helix, which has significant conformational consequences that affect the function of DNA.
Vidarabine (Adenosine arabinoside, ara-A) is an anti-viral drug which is active against herpes simplex and varicella zoster viruses.
Fludarabine (F-ara-A) is an antineoplastic agent which causes inhibition of DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase.[1]
Products & Ordering
ara-Adenosine-5'-monophosphate (ara-AMP)
Vidarabine monophosphate, Sodium salt
ara-Adenosine-5'-triphosphate (ara-ATP)
Vidarabine triphosphate, Sodium Salt
ara-Cytidine-5'-monophosphate (ara-CMP)
Cytarabine monophosphate, Sodium salt
Selected References
[1] Young et al. (1995) Applied Therapeutics. The Clinical Use of Drugs. 6th ed. Vancouver, WA., Applied Therapeutics, Inc., p. 90.
