2',3'-O-Trinitrophenyl-guanosine-5'-triphosphate, Triethylammonium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C16H17N8O20P3
Molecular Weight: 734.27 g/mol
Exact Mass: 733.98 g/mol
Purity: ≥ 95 % (HPLC)
Spectroscopic Properties: λmax 252/408/470 nm, ε 24.1/26.5/18.3 L mmol-1 cm-1 (Tris-HCl pH 7.5), λexc 408/470 nm, λem 552 nm
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Spangler et al. (2011) Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2', (3')-substituted purine and pyrimidine nucleotides. J. Pharmacol. Exp. Ther. 336 (1):234.
Suryanarayana et al. (2009) Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2',3'-O- (2,4,6-Trinitrophenyl)- Substituted Nucleoside 5'-Triphosphates. J. Pharmacol. Exp. Ther. 330 (3):687.
Goettle et al. (2007) Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides. Molecular Pharmacology 72 (3):526.
Sprang et al. (2006) Broad Specifity of Mammalian Adenylyl Cyclase for Interaction with 2',3'-Substituted Purine- and Pyrimidine Nucleotide Inhibitors. Mol. Pharmacol. 70:878.
Golczak et al. (2002) GTP-induced membrane binding and ion channel activity of annexin VI: is annexin VI a GTP biosensor? Biophys. J. 82:2737.
Chordia et al. (1998) Distances between the paclitaxel, colchicine, and exchangeable GTP binding sites on tubulin. Biochemistry 37:6636.
Randak et al. (1996) A recombinant polypeptide model of the second predicted nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator is a GTP-binding protein. FEBS Lett. 398:97.
Baubichon-Cortay et al. (1994) Overexpression and purification of the carboxyl-terminal nucleotide-binding domain from mouse P-glycoprotein. Strategic location of a tryptophan residue. J. Biol. Chem. 269:22983.
Hoyer et al. (1986) Synthesis of 2',3'-O- (2,4,6-trinitrocyclohexadienylidine)guanosine 5'-triphosphate and a study of its inhibitory properties with adenylate cyclase. Arch. Biochem. Biophys. 245:369.
Hiratsuka (1985) A chromophoric and fluorescent analog of GTP, 2',3'-O- (2,4,6-trinitrocyclohexadienylidene)-GTP, as a spectroscopic probe for the GTP inhibitory site of liver glutamate dehydrogenase. J. Biol. Chem. 260:4784.