Inosine-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H15N4O14P3 (free acid)
Molecular Weight: 508.16 g/mol (free acid)
Exact Mass: 507.98 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 100 mM - 110 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 249 nm, ε 12.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Specific and agonistic ligand for P2Y4 receptor
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.
 Vial and Evans (2002) P2X1 receptor-deficient mice establish the native P2X receptor and P2Y6-like receptor in arteries. Molec. Pharmac. 62 (6):1438.
Bao et al. (2008) Coordination of two sequential ester-transfer reactions: exogenous guanosine binding promotes the subsequent wG binding to a group I intron. Nucleic Acids Research 36 (21):6934.
Chang et al. (2005) Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase. J. Biol. Chem. 280 (12):11513.
Bianchi et al. (2001) Intramolecular equilibria in metal ion complexes of guanosine 5 '-triphosphate (GTP (4-)) and inosine 5 '-triphosphate (ITP4-) in aqueous solution. J. Inorg. Biochem. 86 (1):148.
Noji et al. (2001) Purine but not pyrimidine nucleotides support rotation of F (1)-ATPase. J. Biol. Chem. 276 (27):25480.
Chakrabarti et al. (2000) Nucleoside triphosphate specificity of tubulin. Biochemistry 39 (33):10269.
Jacob et al. (2000) Involvement of asparagine 118 in the nucleotide specificity of the catalytic subunit of protein kinase CK2. FEBS Lett. 466 (2-3):363.
Seifert et al. (1999) Effects of guanine, inosine, and xanthine nucleotides on beta (2)-adrenergic receptor/G (s) interactions: evidence for multiple receptor conformations. Mol. Pharmacol. 56 (2):348.
Wang et al. (1999) Identification of residues of Escherichia coli phosphofructokinase that contribute to nucleotide binding and specificity. Biochemistry 38 (14):4313.
Nakahara et al. (1998) Inosine 5 '-triphosphate can dramatically increase the yield of NASBA products targeting GC-rich and intramolecular base-paired viroid RNA. Nucleic Acids Res. 26 (7):1854.
Sasaki et al. (1998) Identification of stable RNA hairpins causing band compression in transcriptional sequencing and their elimination by use of inosine triphosphate. Gene 222 (1):17.
Klinker et al. (1997) Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'- triphosphate with the retinal G-protein, transducin, and with G (i)-proteins in HL-60 leukemia cell membranes. Biochem. Pharmacol. 54 (5):551.
Pollardknight et al. (1987) Kinetics of Hexokinase-D (Glucokinase) with inosine triphosphate as phosphate donor - loss of kinetic cooperativity with respect to glucose. Biochem. J. 245 (3):625.
Chanda et al. (1983) Invitro synthesis of genome length complementary RNA of vesicular stomatitis-virus in the presence of inosine 5'-triphosphate. Virology 129 (1):225.
Morgan et al. (1980) Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosinesubstituted messenger ribonucleic-acids. Biochemistry-US 19 (26):5960.
West (1970) Adenosine triphosphate and inosine triphosphate dependent conformational changes of adenosine diphosphate-G-actin. Biochemistry-US 9 (20):3847.
Azuma et al. (1963) Kinetic studies on hydrolysis of adenosine triphosphate and inosine triphosphate by Myosin A. Biochim. Biophys. Acta 73 (3):499.