P1-(5'-Guanosyl)-P2-(5'-guanosyl)-(3'→5')-diphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C20H26N10O15P2 (free acid)
Molecular Weight: 708.43 g/mol (free acid)
Exact Mass: 708.11 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Spectroscopic Properties: λmax 252 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
The linear diguanylate pGpG is the first phosphodiesterase-catalyzed hydrolysis product of cylic di-GMP (c-diGMP). C-diGMP has been identified as a novel second messenger in bacteria that triggers various physiological changes such as virulence gene expression or cell differentiation[1-5]. The role of pGpG in c-diGMP signalling is under investigation.
 Roemling et al. (2005) C-diGMP: the Dawning of a novel bacterial singalling system. Mol. Microbiol. 57:629.
 Hengge (2009) Principles of c-di-GMP signalling in bacteria. Nat. Rev. Microbiol. 7 (4):263.
 Sudarsan et al. (2008) Riboswitches in Eubacteria Sense the Second Messenger cyclic di-GMP. Science 321:411.
 Rao et al. (2010) YybT is a Signaling Protein that Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity. J. Biol. Chem. 285:473.
 Christen et al. (2007) DgrA is a Member of a New Family of Cyclic Diguanosine Monophosphate Receptors and Controls Flagellar Motor Function in Caulobacter crescentus. Proc. Nat. Acad. Sci. USA 104:4112.