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AP5dT

P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-502S 50 μl (10 mM) 117,35 Add to Basket/Quote Add to Notepad
NU-502L 5 x 50 μl (10 mM) 343,76 Add to Basket/Quote Add to Notepad
Structural formula of AP5dT (P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt)
Structural formula of AP5dT

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C20H30N7O23P5 (free acid)

Molecular Weight: 891.36 g/mol (free acid)

Exact Mass: 891.01 g/mol (free acid)

CAS#: 103137-88-8

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 262 nm, ε 22.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Selected References:
Haouz et al. (2003) Enzymatic and Structural Analysis of Inhibitors Designed against Mycobacterium tuberculosis Thymidylate Kinase. J. Biol. Chem. 278 (7):4963.
Lavie et al. (1998) Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc. Natl. Acad. Sci. USA 95 (24):14045.
Lavie et al. (1998) Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P-1- (5'-adenosyl) P-5- (5'-thymidyl) pentaphosphate (TP (5)A) at 2.0 angstrom resolution: Implications for catalysis and AZT activation. Biochemistry 37:3677.