P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt
For research use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C20H30N7O23P5 (free acid)
Molecular Weight: 891.36 g/mol (free acid)
Exact Mass: 891.01 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 262 nm, ε 22.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
BIOZ Product Citations:
Please click the arrow on the right to expand the citation list. Click publication title for the full text.
Haouz et al. (2003) Enzymatic and Structural Analysis of Inhibitors Designed against Mycobacterium tuberculosis Thymidylate Kinase. J. Biol. Chem. 278 (7):4963.
Lavie et al. (1998) Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc. Natl. Acad. Sci. USA 95 (24):14045.
Lavie et al. (1998) Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P-1- (5'-adenosyl) P-5- (5'-thymidyl) pentaphosphate (TP (5)A) at 2.0 angstrom resolution: Implications for catalysis and AZT activation. Biochemistry 37:3677.