ara-Cytidine-5'-triphosphate (ara-CTP)
For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H16N3O14P3 (free acid)
Molecular Weight: 483.16 g/mol (free acid)
Exact Mass: 482.98 g/mol (free acid)
CAS#: 13191-15-6
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 271 nm, ε 8.9 L mmol-1 cm-1 (Tris-HCl pH 7.0)
Applications:
Treatment of acute myeloid leukemia[1]
Inhibition of DNA synthesis by incorporation[2]
Detection with isocratic HPLC[3]
Inhibition of DNA ligases and polymerases[4]
Selected References:
[1] Negoro et al. (2011) Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 38 (4):911.
[2] Yamauchi et al. (2009) Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. Biochem. Pharmacol. 77 (12):1780.
[3] Nishi et al. (2006) A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography. Cancer Sci. 97 (11):1274.
[4] Colón-Cesario et al. (2006) An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning. J. Neurosci. 26 (20):5524.
| Cat. No. | Amount | Price |
|---|---|---|
| NU-1170S | 100 μl (10 mM) | 165,40 € |
| NU-1170L | 5 x 100 μl (10 mM) | 484,60 € |
At this point, external content from bioz.com is embedded. When it loads, data (e.g. your IP address) is transmitted to the provider.
