Cytarabine triphosphate, Sodium salt
Cytidine-arabinofuranoside-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H16N3O14P3 (free acid)
Molecular Weight: 483.16 g/mol (free acid)
Exact Mass: 482.98 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 271 nm, ε 8.9 L mmol-1 cm-1 (Tris-HCl pH 7.0)
Treatment of acute myeloid leukemia
Inhibition of DNA synthesis by incorporation
Detection with isocratic HPLC
Inhibition of DNA ligases and polymerases
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 Negoro et al. (2011) Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 38 (4):911.
 Yamauchi et al. (2009) Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. Biochem. Pharmacol. 77 (12):1780.
 Nishi et al. (2006) A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography. Cancer Sci. 97 (11):1274.
 Colón-Cesario et al. (2006) An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning. J. Neurosci. 26 (20):5524.