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m7GMP

7-Methyl-guanosine-5'-monophosphate, Triethylammonium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-1135S 100 μl (10 mM) 120,23 Add to Basket/Quote Add to Notepad
NU-1135L 5 x 100 μl (10 mM) 352,15 Add to Basket/Quote Add to Notepad
Structural formula of m7GMP (7-Methyl-guanosine-5'-monophosphate, Triethylammonium salt)
Structural formula of m7GMP

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C11H16N5O8P (free acid)

Molecular Weight: 377.25 g/mol (free acid)

CAS#: 47442-17-1

Purity: ≥ 95 % (HPLC)

Form: clear aqueous solution

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 258/280 nm, ε 9.8/8.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Association to human scavenger decapping enzyme[1]
Inhibition of methyltransferase activity[2]

Selected References:
[1] Darzynkiewicz et al. (2007) Interaction of human decapping scavenger with 5-mRNA cap analogues: structural requirements for catalytic activity. Journal of Physics: Condensed Matter 19:285217/1.
[2] Magden et al. (2001) Virus-specific mRNA capping enzyme encoded by hepatitis E virus. J. Virology 75:6249.
Shen et al. (2001) Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods. Chem Pharm Bull 49 (10):1299.
Carberry et al. (1989) A spectroscopic study of the binding of m7GTP and m7GpppG to human protein synthesis initiation factor 4E. Biochemistry 28 (20):8078.
Beemon et al. (1977) In vitro translation yields a possible Rous sarcoma virus src gene product. Proc Natl Acad Sci U S A. 74 (8):3302.