Nucleoside-2',3'-cyclic-phosphate esters are intermediates in the ribonuclease-catalyzed hydrolysis of ribonucleic acids, and are themselves substrates for ribonuclease[1]. Nucleoside-2',3'-cyclic monophosphates are studied as model substrates for kinetic analyses of various ribonucleases[2].
Evidence started to emerge recently that nucleoside-2',3'-cyclic monophosphates might also play important roles in regulating biological processes[3].
[1] Bernfield (1965) Ribonuclease and oligoribonucleotide synthesis. The Journal of Biological Chemistry 240 (12):4753.
[2] Köditz et al. (2002) pH-Stat Titration allows the continuous determination of ribonuclease A activity toward cytidine-2’,3’-cyclic monophosphate at high substrate concentrations. Analytical Biochemistry 305:281.
[3] Bordeleau et al. (2014) Identification of cytidine 2’,3’-cyclic monophosphate and uridine 2’,3’-cyclic monophosphate in Pseudomonas fluorescens pfo-1 culture. Bioorganic & Medicinal Chemistry Letters 24:4520.