DBCO-containing Nucleotides

Dibenzocyclooctyne (DBCO)^*-containing nucleotides can be attached to Azide-tagged biomolecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC).

Search for nucleotides that are suitable for enzymatic click functionalization of DNA or enzymatic click functionalization of RNA

^*DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne)