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DBCO-containing Fluorescent Dyes

Dibenzocyclooctyne (DBCO)*-containing fluorescent dyes can be used for the fluorescent labeling of Azide-tagged biomolecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC). Both Standard Dyes (e.g. Cy3, Tamra or Texas Red) and novel Alternative Dyes have been thoroughly selected to cover the whole UV-Vis spectrum.

*DBCO is also known as ADIBO (= Azadibenzocyclooctyne)

 

Table 1: Available DBCO-containing Fluorescent Dyes

Emission
color
DyeProduct
blue-greenATTO 425DBCO-PEG4-ATTO-425
greenBDP-FL
(also known as BODIPY® FL)
BDP-FL-PEG4-DBCO
5/6-Fluorescein (5/6-FAM)DBCO-PEG4-5/6-FAM
AF488
(also known as Alexa Fluor®488)
DBCO-AF488
ATTO 488DBCO-PEG4-ATTO-488
5/6-Carboxyrhodamine 110DBCO-PEG4-5/6-Carboxyrhodamine 110
yellow5/6-TAMRADBCO-PEG4-5/6-TAMRA
Sulfo-Cy3DBCO-Sulfo-Cy3
5/6-Sulforhodamine BDBCO-PEG4-5/6-Sulforhodamine B
orange5/6-Texas RedDBCO-PEG4-5/6-Texas Red
AF594
(also known as Alexa Fluor®594)
DBCO-AF594
redSulfo-Cy5DBCO-Sulfo-Cy5
Cy5.5DBCO-Cy5.5
near-IRCy7DBCO-Cy7