Bifunctional DBCO-containing Reagents

Dibenzocyclooctyne (DBCO)^*-containing bifunctional reagents can be used for the introduction of

• a functional group to Azide-labeled molecules via Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC)
• an DBCO group to various targets e.g. via NHS Ester- or Maleimide-based chemistry

^*DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne)