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2',3'-cGAMP

cyclic-[G(2',5')pA(3',5')p]

Cyclic-(guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-249S 1 μmol 103,00 Add to Basket/Quote Add to Notepad
NU-249L 5 x 1 μmol 412,10 Add to Basket/Quote Add to Notepad
Structural formula of 2',3'-cGAMP (cyclic-[G(2',5')pA(3',5')p], Cyclic-(guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), Sodium salt)
Structural formula of 2',3'-cGAMP

For research use only!

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C20H24N10O13P2 (free acid)

Molecular Weight: 674.42 g/mol (free acid)

Exact Mass: 674.10 g/mol (free acid)

Purity: ≥ 95 % (HPLC)

Form: solid

Color: white to off-white

Spectroscopic Properties: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Selected References:
Li et al. (2018) The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer. J. Exp. Med. 215 (5):1287.
Li et al. (2016) Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response. Nature Scientific Reports 6:19049.
Tao et al. (2016) cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling. IUBMB Life 68 (11):858.
Temizoz et al. (2015) TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur. J. Immunol. 45:1159.