ara-Cytidine-5'-triphosphate (ara-CTP)

For general laboratory use.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C₉H₁₆N₃O₁₄P₃ (free acid)

Molecular Weight: 483.16 g/mol (free acid)

Exact Mass: 482.98 g/mol (free acid)

CAS#: 13191-15-6

Purity: ≥ 95 % (HPLC)

Form: solution in water

Color: colorless to slightly yellow

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λ_max 271 nm, ε 8.9 L mmol^-1 cm^-1 (Tris-HCl pH 7.0)

Applications:
Treatment of acute myeloid leukemia^[1]
Inhibition of DNA synthesis by incorporation^[2]
Detection with isocratic HPLC^[3]
Inhibition of DNA ligases and polymerases^[4]

BIOZ Product Citations:

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Selected References:
[1] Negoro et al. (2011) Characterization of cytarabine-resistant leukemic cell lines established from five different blood cell lineages using gene expression and proteomic analyses. Int. J. Oncol. 38 (4):911.
[2] Yamauchi et al. (2009) Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. Biochem. Pharmacol. 77 (12):1780.
[3] Nishi et al. (2006) A new, simple method for quantifying gemcitabine triphosphate in cancer cells using isocratic high-performance liquid chromatography. Cancer Sci. 97 (11):1274.
[4] Colón-Cesario et al. (2006) An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning. J. Neurosci. 26 (20):5524.