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6-Methylthioinosine-5'-monophosphate, Triethylammonium salt


Cat. No. Amount Price (EUR) Buy / Note
NU-1131S 150 μl (10 mM)150,10 Add to Basket/Quote Add to Notepad
NU-1131L 5 x 150 μl (10 mM)439,50 Add to Basket/Quote Add to Notepad
Structural formula of 6-Methylthio-IMP (6-Methylthioinosine-5'-monophosphate, Triethylammonium salt)
Structural formula of 6-Methylthio-IMP

For general laboratory use.

Shipping: shipped on gel packs

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C11H15N4O7PS (free acid)

Molecular Weight: 378.29 g/mol (free acid)

Exact Mass: 378.04 g/mol (free acid)

CAS#: 7021-52-5

Purity: ≥ 95 % (HPLC)

Form: solution in water

Color: colorless to slightly yellow

Concentration: 10 mM - 11 mM

pH: 7.5 ±0.5

Spectroscopic Properties: λmax 224/292 nm, ε 11.5/19.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Catabolism by purine-5'-nucleotidase[1]
Transport by multidrug resistance proteins MRP4 and MRP5[2]
Strong inhibitor of purine synthesis de novo[3]

BIOZ Product Citations:

Selected References:
[1] Brouwer et al. (2005) Role of 5'-nucleotidase in thiopurine metabolism:Enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment. Clinica Chemica Acta 361:95.
[2] Wielinga et al. (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Molecular Pharmacology 62:1321.
[3] Stet et al. (1994) Decrease of S-adenosylmethionine synthesis by 6-mercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts. Biochemical J. 304:163.
Lavi et al. (1985) A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells. Anal. Biochem. 144 (2):514.