6-Mercaptopurine-riboside-5'-triphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C10H15N4O13P3S (free acid)
Molecular Weight: 524.22 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: clear aqueous solution
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 322 nm, ε 27.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Competitive inhibitor of T4 RNA ligase
Kinetic parameters with thiopurine methyltransferase
Interaction with (sodium-potassium ion)-dependent ATPase
 Labeikyte et al. (1995) Structural features of nucleotide binding in T4 RNA ligase determined from inhibition by structural analogs of ATP. Biologija 3:13.
 Deininger et al. (1994) Purine substrates for human thiopurine methyltransferase. Biochemical Pharmacology 48:2135.
 Erdmann et al. (1976) The cardiac glycoside receptor: its properties and its correlation to nucleotide binding sites, phosphointermediate, and Na-K-dependent ATPase activity. Recent Adv. Stud. Cardiac Struct. Metab. 9:329.
Bierau et al. (2007) Pharmacogenetic significance of inosine triphosphatase. Pharmacogenomics 8 (9):1221.
Patzelt et al. (1974) Study of (Na+K)-ATPase with 6-chloropurine triphosphate, 6-mercaptopurine triphosphate and dinitrophenyl-6-thiopurine triphosphate. H-S Z. Physiol. Chem. 355 (10):1237.