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Protein Prenylation: Lipid Donors

Innovative lipid donors have been developed for sensitive prenylation assays. NBD-FPP and NBD-GPP are a well-established fluorescent analogs of the natural lipid donors.
B-GPP is the first universal lipid donor for all prenylatable proteins, providing versatile prenylation assays with femtomolar detection sensitivity.

Selected References

Nguyen et al. (2009) Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nature Chemical Biology. 5 (4):227
Wu et al. (2007) Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase. Nat. Protoc. 2 (11):2704
Dursina et al. (2006) Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J. Am. Chem. Soc. 128 (9):2822