Biotin-labeled geranyl pyrophosphate, triethylammonium salt
For general laboratory use.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
avoid freeze/thaw cycles
Shelf Life: 12 months
Molecular Formula: C20H35N3O9P2S
Molecular Weight: 555.52 g/mol
Purity: mass identification conforms (ESI-MS)
Form: liquid (Supplied as 1 mM solution in 25 mM (NH4)2CO3)
Concentration: 1 mM
B-GPP is a biotin-labeled analog of geranyl pyrophosphate (GPP). It serves as lipid donor for the native RabGGTase and mutants of GGTase-I and FTase. B-GPP allows for straightforward mammalian prenylome labeling and thus, not only identifying protein prenyltransferase substrates but efficiently screening for new inhibitors.
BIOZ Product Citations:
Kovtun et al. (2010) Towards the construction of expressed proteomes using a Leishmania tarentolae based cell-free expression system. PLoS One. 5 (12):e14388.
Nguyen et al. (2009) Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nature Chemical Biology. 5 (4):227.