Prenylation - FTase Substrates and Related Proteins

Since the initial discovery of farnesylated fungal proteins, many more proteins have been demonstrated to contain a prenyl modification. Today it's well-known, that protein prenylation affects up to 2% of the proteins in the mammalian proteome.

The proteins listed below are FTase substrates and corresponding proteins.
A farnesyl moiety is attached to the cysteine of the so called CaaX box, a C-terminal motif required for farnesylation.
Please note that deletion mutants with truncated C-terminus are not recognized by the protein farnesyltransferase and will thus not be farnesylated.