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ATP-y-F

(ApppF)

Adenosine-5'-(γ-fluoro)-triphosphate, Sodium salt

Adenosine-5'-(3-fluoro)-triphosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-942-5 5 mg 105,08 Add to Basket/Quote Add to Notepad
NU-942-25 25 mg 420,31 Add to Basket/Quote Add to Notepad
Structural formula of ATP-y-F ((ApppF), Adenosine-5'-(γ-fluoro)-triphosphate, Sodium salt)
Structural formula of ATP-y-F

For in vitro use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C10H15FN5O12P3 (free acid)

Molecular Weight: 509.17 g/mol (free acid)

Exact Mass: 508.99 g/mol (free acid)

CAS#: 37515-63-2 (free acid), 1698010-87-5 (sodium salt)

Purity: ≥ 95 % (HPLC)

Form: solid

Spectroscopic Properties: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
Substrate for snake venom phosphodiesterase [1,2]
Inhibitor of Lysyl-, Valyl- and Arginyl-tRNA synthases [3]
Substrate for Fhit proteins [1,4]

Selected References:
[1] Baranowski et al. (2015) Synthesis of fluorophosphate nucleotide analogues and their characterization as tools for ¹⁹F NMR studies. J. Org. Chem. 80 (8):3982.
[2] Haley et al. (1972) g-Fluoroadenosine triphosphate. Synthesis, properties, and interaction with myosin and heavy meromyosin. Biochemistry 11 (15):2863.
[3] Freist et al. (1980) Chemically modified ATP derivatives for the study of aminoacyl-tRNA synthetases from Bakers' yeast: ATP analogs with fixed conformations of modified triphosphate chains in the aminoacylation reaction Bioorganic Chemistry 9 (4):491.
[4] Guranowski et al. (2008) Fhit proteins can also recognize substrates other than dinucleoside polyphosphates. FEBS Lett. 582 (20):3152.