P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate, Sodium salt
For research use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C20H30N10O25P6 (free acid)
Molecular Weight: 996.35 g/mol (free acid)
Exact Mass: 995.98 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Kinetic parameters with arabidopsis thaliana Nudix hydrolase
Action as neurotransmitter
Modeling of binding to Nudix hydrolase Ndx1
Mediated release of atrial atriopeptin (ANP)
Binding properties to Nudix hydrolase
BIOZ Product Citations:
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 Olejnik et al. (2007) Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates. FEBS J. 274 (18):4877.
 Delicado et al. (2006) Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. Pflugers Arch. 452 (5):563.
 Zheng et al. (2005)Homology modeling and substrate binding study of Nudix hydrolase Ndx1 from Thermos thermophilus HB8. Biochem. Biophys. Res. Commun. 333 (3):881.
 Yuan et al. (2007) Diadenosine tetraphosphate stimulates atrial ANP release via A (1) receptor: involvement of K (ATP) channel and PKC. Peptides 28 (7):1397.
 Garza et al. (2009) Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe. Biochemistry 48 (26):6224.
Gross et al. (2006) Nucleotide-binding domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but not ATP Hydrolysis. J. Biol. Chem. 281 (7):4058.
Luo et al. (1999) Identification of diadenosine hexaphosphate in human erythrocytes. Hypertension 34:872.
Van der Giet et al. (1999) Evidence for two different P2X-receptors mediating vasoconstriction of Ap5A and Ap6A in the isolated perfused rat kidney. Br. J. Pharmacol. 127:1463.
Fontes et al. (1999) Acyl-CoA synthetase catalyzes the synthesis of diadenosine hexaphosphate (Ap6A). Biochimie 81:229.
Schluter et al. (1994) Diadenosine phosphates and the physiological control of blood pressure. Nature 367:186.
Morii et al. (1992) Adenosine (5')hexaphospho (5')adenosine stimulation of a Ca (2+)-induced Ca (2+)-release channel from skeletal muscle sarcoplasmic reticulum. Eur. J. Biochem. 205:979.