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Thymidines

Azide-containing nucleotides can be attached to terminal Alkyne- or strained Alkyne (e.g. DBCO)-tagged biomolecules via Cu(I)-catalyzed Alknye-Azide (CUAAC) or Cu(I)-free strain-promoted Alkyne-Azide Click Chemistry (SPAAC) reaction, respectively.

Search for nucleotides that are suitable for
enzymatic click functionalization of DNA or enzymatic click functionalization of RNA.