Guanosine-5'-(β-thio)-diphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 6 months after date of delivery
Molecular Formula: C10H15N5O10P2S (free acid)
Molecular Weight: 459.26 g/mol (free acid)
Purity: ≥ 90 % (HPLC)
Spectroscopic Properties: λmax 252 nm, ε 13.7 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Please note: For reasons of stability, please make sure that the pH value of a solution of this product never drops below 7.0. This can be achieved by dissolving the nucleotide in a buffer of your choice (50 - 100 mM, pH 7 - 10). Dissolve and adjust concentration photometrically.
Chang et al. (2005) Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase. J. Biol. Chem. 280 (12):11513.
Balttus et al. (2002) Spontaneous release of GDP from Gi proteins and inhibition of adenylyl cyclase in cardiac sarcolemmal membranes. Naunyn Schmiedebergs Arch. Pharmacol. 365 (1):50.
Burgos et al. (2000) Guanine nucleotides block agonist-driven 45Ca2+ influx in chick embryo retinal explants. Neuroreport. 11 (10):2303.
Peterson et al. (1999) GTP (gammaS) and GDP (betaS) as electron donors: new wine in old bottles. Life Sci. 65 (11):1135.