Guanosine-5'-(β-thio)-diphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 6 months after date of delivery
Molecular Formula: C10H15N5O10P2S (free acid)
Molecular Weight: 459.26 g/mol (free acid)
Exact Mass: 459.00 g/mol (free acid)
Purity: ≥ 90 % (HPLC)
Color: white to off-white
Spectroscopic Properties: λmax 252 nm, ε 13.7 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Please note: For reasons of stability, please make sure that the pH value of a solution of this product never drops below 7.0. This can be achieved by dissolving the nucleotide in a buffer of your choice (50 - 100 mM, pH 7 - 10). Dissolve and adjust concentration photometrically.
Please click the black arrow on the right to expand the citation list. Click publication title for the full text.
Chang et al. (2005) Nitric Oxide-dependent Allosteric Inhibitory Role of a Second Nucleotide Binding Site in Soluble Guanylyl Cyclase. J. Biol. Chem. 280 (12):11513.
Balttus et al. (2002) Spontaneous release of GDP from Gi proteins and inhibition of adenylyl cyclase in cardiac sarcolemmal membranes. Naunyn Schmiedebergs Arch. Pharmacol. 365 (1):50.
Burgos et al. (2000) Guanine nucleotides block agonist-driven 45Ca2+ influx in chick embryo retinal explants. Neuroreport. 11 (10):2303.
Peterson et al. (1999) GTP (gammaS) and GDP (betaS) as electron donors: new wine in old bottles. Life Sci. 65 (11):1135.