2'/3'-O-(N-Methyl-anthraniloyl)-guanosine-5'-[(β,γ)-imido]triphosphate, Triethylammonium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 6 months after date of delivery
Molecular Formula: C18H24N7O14P3 (free acid)
Molecular Weight: 655.34 g/mol (free acid)
Purity: ≥ 90 % (HPLC)
Form: colorless to slightly yellow solution in water
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 252/355 nm, ε 22.6/5.7 L mmol-1 cm-1 (Tris-HCl pH 7.5), λexc 355 nm, λem 448 nm
Inhibition of AC-isoforms[1, 2]
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Wehner et al. (2012) The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis. FEBS J. 279 (2):203.
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Pick et al. (2006) Liposomes Comprising Anionic but not neutral Phospholipids cause dissociation of Rac (1 or 2)RhoGDI Complexes and support Amphiphile-independent NADPH oxidase Activation by Such Complexes. J. Biol. Chem. 281 (28):19204.
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Neal et al. (1990) Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site. Proc. Natl. Acad. Sci. USA 87:3562.