3',3'-cGAMP
For research use only.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C20H24N10O13P2 (free acid)
Molecular Weight: 674.41 g/mol (free acid)
Exact Mass: 674.10 g/mol (free acid)
Purity: ≥ 98 % (HPLC) / ≤ 2.5 EU/ml Endotoxin (LAL test)
Form: solid (lyophilized from filtered (10 kDa) solution in water)
Color: white to off-white
Spectroscopic Properties: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Selected References:
Wenzl et al. (2024) How enzyme-centered approaches are advancing research on cyclic oligo-nucleotides. FEBS Lett.598(8): 839.
| Cat. No. | Amount | Price |
|---|---|---|
| NU-986S | 1 μmol | 132,50 € |
| NU-986L | 5 x 1 μmol | 530,60 € |
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Scientific citations for Jena Bioscience nu-986
3 scientific citations and 0 citation images found by Bioz.
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Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center.
Structure (London, England : 1993), 2026-02-24 · PMID:41742401
.. et al. 23 https://doi.org/10.1016/j.ejmech.2023.115685 MD1233C Dejmek et al. 23 https://doi.org/10.1016/j.ejmech.2023.115685 c-di-AMP Jena Bioscience Cat#NU-954L c-di-GMP Jena Bioscience Cat#NU-951L 3 ′ 3’cGAMP Jena Bioscience Cat
NU-986 L 2 ′ 3’cGAMPJena Bioscience Cat#NU-249L Deposited data DhhP/AMP (native) This paper PDB: 9R7O DhhP/AMP (SAD/Mn) This paper PDB: 9R97 DhhP/AMP (SAD/Fe) This paper PDB: 9R98 DhhP/MD1252 This .. -
Single-stranded DNA binding to the transcription factor PafBC triggers the mycobacterial DNA damage response.
Science Advances, 2025-02-07 · PMID:39919186
Nucleotide second messengers including cAMP, cGMP (cyclic GMP), cyclic- di- AMP (cyclic diadenosine monophosphate), cyclic- di- GMP (cyclic diguanosine monophosphate),
2′,3′- cGAMP and 3′,3′- cGAMP, ppGpp (guanosine- 3′,5′- bisdiphosphate), and pppGpp (all derived fromJena Bioscience ) were dissolved in water and then frozen and stored at −20°C until further use. -
Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import
bioRxiv, 2024-09-24 · DOI:10.1101/2024.09.21.614248
PrePrint: To synthesize
3’3’-cGAMP diazirine probe , 1 mM of 6’Cl ATP (Jena Biosciences ) and 1 mM of GTP (Sigma-Aldrich) were mixed in 20 mM of Tris-HCl at pH 7.4 and 20 mM of MgCl 2 .. Subsequently, 200 nM of purified DncV was added, and the reaction mixture was stirred ..
