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Tenofovir

[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid

(R)-9-(2-phosphonylmethoxypropyl)adenine

PMPA

Cat. No. Amount Price (EUR) Buy / Note
NU-974 100 mg 43,41 Add to Basket/Quote Add to Notepad
Structural formula of Tenofovir ([(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid)
Structural formula of Tenofovir

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C9H14N5O4P (free acid)

Molecular Weight: 287.21 g/mol (free acid)

Exact Mass: 287.08 g/mol (free acid)

CAS#: 147127-20-6

Purity: ≥ 98 % (HPLC)

Form: solid

Spectroscopic Properties: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Selected References:
Krejčová et al. (2000) Phosphorylation of Purine (Phosphonomethoxy)alkyl Derivatives by Mitochondrial AMP Kinase (AK2 Type) from L1210 Cells. Collect. Czech. Chem. Commun. 65:1653.
Robbins et al. (1998) Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob. Agents Chemother. 42(3):612.
Robbins et al. (1995) Metabolic Pathways for Activation of the Antiviral Agent 9-(2-Phosphonylmethoxyethyl)Adenine in Human Lymphoid Cells. Antimicrob. Agents Chemother. 39(10):2304.