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Vinyl-containing Nucleotides

Vinyl-containing nucleotides can be labeled with Tetrazine-tagged reporter molecules via Copper-free Tetrazine-Alkene Ligation that allows to introduce a Biotin group for subsequent purification (via Tetrazine-containing Biotinylation Reagents → Click Chemistry) or a fluorescent group for subsequent microscopic imaging (via Tetrazine-containing Fluorescent Dyes → Click Chemistry).

Search for nucleotides that are suitable for enzymatic click functionalization of DNA → Click Chemistry or enzymatic click functionalization of RNA → Click Chemistry