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Tetrazine-containing Fluorescent Dyes

Tetrazine-containing fluorescent dyes are suitable for fluorescent labeling of Cyclooctene-labeled molecules via Cu-free Click Chemistry. Both Standard Dyes (e.g. Cy3 or Tamra) and novel Alternative Dyes have been thoroughly selected to cover the whole UV-Vis spectrum.

Two Tetrazine versions with different reactivities and stability characteristics are available to meet specific application requirements. Tetrazine reagents are the ideal choice if a rapid reaction kinetic is the key aspect whereas 6-Methyl-Tetrazine reagents are ideally suited if an improved chemical stability is required [1].

 

Table 1: Available Tetrazine-containing Fluorescent Dyes

Selected References

[1] Karver et al. (2011) Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugations. Am. Chem. Soc. 22:2263.