N6-(6-Azido)hexyl-dATP
For research use only.
Please centrifuge briefly before opening (volume ≤2 ml).
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C16H27N8O12P3 (free acid)
Molecular Weight: 616.35 g/mol (free acid)
Exact Mass: 616.10 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Form: solution in water
Color: colorless to slightly yellow
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 266 nm, ε 16.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Selected References:
Ando et al. (2019) ELTA: Enzymatic Labeling of Terminal ADP-Ribose. Mol. Cell. 73 (4):845.
| Cat. No. | Amount | Price |
|---|---|---|
| CLK-NU-002-S | 50 μl (10 mM) | 157,60 € |
| CLK-NU-002-L | 5 x 50 μl (10 mM) | 461,30 € |
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Scientific citations for Jena Bioscience clk-nu-002
8 scientific citations and 0 citation images found by Bioz.
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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection.
Nature Communications, 2025-12-17 · PMID:41407686
First, peptides were incubated with 100 μM N6-(
6-Azido )hexyl-dATP (Jena Bioscience CLKNU-002), 20 μg/mL low molecular weight poly(I:C) (Invivogen tlrlpicw), and 20 μg/mL human 2 ́-5 ́-oligoadenylate synthase 1 (OAS1; prepared in-house as in ref. 31) in buffer containing 100mM Tris-HCl pH7.5, 20mMmagnesiumacetate, and2.5mMdithiothreitol (DTT) for 1 h at 37 °C while shaking at 800 rpm. -
dELTA-MS: A Mass Spectrometry-Based Proteomics Approach for Identifying ADP-ribosylation Sites and Forms
Journal of Proteome Research, 2025-04-04 · PMID:40079415
.. 6 nmol of H3(1-20)S10arn was spiked into each technical replicate.. First, peptides were incubated with 100 μM N6-(
6-Azido )hexyl-dATP (Jena Bioscience ), 20 μg/mL low molecular weight poly(I:C), and 80 μg/mL OAS1 in buffer containing 100 mM Tris-HCl pH 7.5, 20 mM magnesium acetate, and 2.5 mM dithiothreitol (DTT) for 1 h at 37°C and shaking at 800 rpm.. 100 μL of 50% DBCO-agarose equilibrated in 1x PBS was .. -
In Vivo Polymer Mechanochemistry with Polynucleotides.
Advanced Materials, 2024-05-28 · PMID:38804595
Abstract: Polymer mechanochemistry utilizes mechanical force to activate latent functionalities in macromolecules and widely relies on ultrasonication techniques. Fundamental constraints of frequency and power intensity have prohibited the application of the polymer mechanochemistry principles in a biomedical context up to now, although medical ultrasound is a clinically established modality. Here, a universal polynucleotide framework is presented that allows the binding and release of therapeutic oligonucleotides, both DNA- and RNA-based, as cargo by biocompatible medical imaging ultrasound
