» Sign in / Register

Guanosines labeled with Photo-labile groups ("Caged")

"Caged" nucleotides contain a photolabile group that renders them biologically inactive. Flash photolysis of the caging group by ultraviolet light leads to a rapid and highly localized release of the biologically active nucleotide from the inactive caged species.

"Caged" nucleotides are used for:

  • Monitoring of fast kinetics
  • Time-resolved X-ray crystallography
  • Identification and chracaterization of drug targets