ATP-acetyl-Desthiobiotin

For general laboratory use.

Shipping: shipped on dry ice

Storage Conditions: store at -80 °C

Shelf Life: 6 months after date of delivery

Molecular Formula: C₂₀H₃₂N₇O₁₅P₃ (free acid)

Molecular Weight: 703.43 g/mol (free acid)

Exact Mass: 703.12 g/mol (free acid)

Purity: ≥ 75 % (HPLC)

Form: solid

Color: colorless to white

Spectroscopic Properties: λ_max 259 nm, ε 15.3 L mmol^-1 cm^-1 (Tris-HCl pH 7.5)

Please note:

• Minimize exposure of the product to ambient temperature and store unused product at -80 °C.
• Avoid repeated freeze/thaw cycles.
• Do not prepare stock solutions for storage.
• Equilibrate vial to room temperature before opening and use it immediately.
• The product is typically not visible in the vial.

Selected References:
Okerberg et al. (2019) Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6. Biochemistry. doi:10.1021/acs.biochem.9b00290.
Nordin et al. (2015) ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement. Biochemistry. 54 (19):3024.
Adachi et al. (2014) Proteome-wide discovery of unknown ATP-binding proteins and kinase inhibitor target proteins using an ATP probe. J. Proteome Res. 13 (12):5461.
Edgar et al. (2014) A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Biosci. Rep. 34 (1):e00091.