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Guanosine-5'-[(α,β)-methyleno]diphosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-414-5 5 mg 128,90 Add to Basket/Quote Add to Notepad
NU-414-25 25 mg 415,50 Add to Basket/Quote Add to Notepad
Structural formula of GpCp ((GMPCP), Guanosine-5'-[(α,β)-methyleno]diphosphate, Sodium salt)
Structural formula of GpCp

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C11H17N5O10P2 (free acid)

Molecular Weight: 441.23 g/mol (free acid)

Exact Mass: 441.05 g/mol (free acid)

CAS#: 32381-15-0

Purity: ≥ 95 % (HPLC)

Form: solid

Color: white to off-white

Spectroscopic Properties: λmax 252 nm, ε 13.7 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Hydrolysis by tubulin[1]
Influence on Z-DNA conformation[2]

Selected References:
[1] Caplow et al. (1994) The free energy of hydrolysis of a microtubule-bound nucleotide triphosphate is near zero: All of free energy for hydrolysis is stored in microtubule lattice. J. Cell Biology 127:779.
[2] Ban et al. (1996) Crystal structure of the self-complementary 5'-purine start decamer d (GCGCGCGCGC) in the Z-DNA conformation. Biophysical J. 71:1215.
[3] Inoue et al. (1969) Low-field proton magnetic resonance spectra for seven dinucleotides ApCp, ApGp, ApUp, CpGp, GpCp, GpUp, and UpGp. Physiological Chemistry and Physics 1:77.
Martin-Galiano et al. (2011) Bacterial tubulin distinct loop sequences and primitive assembly properties support its origin from a eukaryotic tubulin ancestor.J. Biol. Chem. 286 (22):19789.
Muller-Reichert et al. (1998) Structural changes at microtubule ends accompanying GTP hydrolysis: information from a slowly hydrolyzable analogue of GTP, guanylyl (alpha,beta)methylenediphosphonate. Proc. Natl. Acad. Sci. USA 95 (7):3661.
Vulevic et al. (1997) Role of guanine nucleotides in the vinblastine-induced self-association of tubulin: effects of guanosine alpha,betamethylenetriphosphate and guanosine alpha,beta-methylenediphosphate. Biochemistry-US 36 (42):12828.
Hyman et al. (1995) Structural-changes accompanying GTP hydrolysis in microtubules - information from a slowly hydrolyzable analog guanylyl- (alpha,beta)-methylene-diphosphonate. J. Cell Biol. 128 (1-2):117.
Hyman et al. (1992) Role of GTP hydrolysis in microtubule dynamics - information from a slowly hydrolyzable analog, GMPCPP. Mol. Biol. Cell 3 (10):1155.

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