Adenosine-5'-[(α,β)-methyleno]diphosphate, Sodium salt
For research use only!
Shipping: shipped on blue ice
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C11H17N5O9P2 (free acid)
Molecular Weight: 425.23 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Spectroscopic Properties: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)
X-ray studies with selenophosphate synthetase 1
Inhibition of ecto phosphodiesterase DPSPX and ecto nucleodidase AMPCP
Inhibition of 5'-nucleotidase
Agonistic ligand, mainly for nucleoside receptor A1
Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors.
 Wang et al. (2009) Crystal structures of catalytic intermediates of human selenophosphate synthetase 1. J. Mol. Biol. 390 (4):747.
 Chiavegatti et al. (2008) Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway. Br. J. Pharmacol. 153 (6):1331.
 Müller et al. (2008) Inhibition of lipolysis by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes depends on cAMP degradation by lipid droplets. Biochemistry 47 (5):1259.
Panther et al. (2012) AMP affects intracellular Ca2+ signaling, cytokine secretion and T-cell priming capacity of dendritic cells. PLos One 7 (5):e37560.
Cometti et al. (2003) Oviduct cells express the cyclic AMP-adenosine pathway. Biol. Reprod. 69 (3):868.
Park et al. (1999) Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adnosine 5-diphosphate (ADP) in human platelets. Br. J. Pharmacol. 127 (6):1359.
Ragazzi et al. (1991) Electrophysiological and receptor binding studies to assess activation of the cardiac adenosine receptor by adenine nucleotides. Circulation Res. 68 (4):1035.