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ApCp

(AMPCP)

Adenosine-5'-[(α,β)-methyleno]diphosphate, Sodium salt

Cat. No. Amount Price (EUR) Buy / Note
NU-420-5 5 mg 104,04 Add to Basket/Quote Add to Notepad
NU-420-25 25 mg 374,54 Add to Basket/Quote Add to Notepad
Structural formula of ApCp ((AMPCP), Adenosine-5'-[(α,β)-methyleno]diphosphate, Sodium salt)
Structural formula of ApCp

For research use only!

Shipping: shipped on blue ice

Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Shelf Life: 12 months after date of delivery

Molecular Formula: C11H17N5O9P2 (free acid)

Molecular Weight: 425.23 g/mol (free acid)

CAS#: 3768-14-7

Purity: ≥ 95 % (HPLC)

Form: solid

Spectroscopic Properties: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Applications:
X-ray studies with selenophosphate synthetase 1[1]
Inhibition of ecto phosphodiesterase DPSPX and ecto nucleodidase AMPCP[2]
Inhibition of 5'-nucleotidase[3]
Agonistic ligand, mainly for nucleoside receptor A1
Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors.

Selected References:
[1] Wang et al. (2009) Crystal structures of catalytic intermediates of human selenophosphate synthetase 1. J. Mol. Biol. 390 (4):747.
[2] Chiavegatti et al. (2008) Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway. Br. J. Pharmacol. 153 (6):1331.
[3] Müller et al. (2008) Inhibition of lipolysis by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes depends on cAMP degradation by lipid droplets. Biochemistry 47 (5):1259.
Panther et al. (2012) AMP affects intracellular Ca2+ signaling, cytokine secretion and T-cell priming capacity of dendritic cells. PLos One 7 (5):e37560.
Cometti et al. (2003) Oviduct cells express the cyclic AMP-adenosine pathway. Biol. Reprod. 69 (3):868.
Park et al. (1999) Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adnosine 5-diphosphate (ADP) in human platelets. Br. J. Pharmacol. 127 (6):1359.
Ragazzi et al. (1991) Electrophysiological and receptor binding studies to assess activation of the cardiac adenosine receptor by adenine nucleotides. Circulation Res. 68 (4):1035.