UTP - Solution
For research use only.
Please centrifuge briefly before opening (volume ≤2 ml).
Description:
Ultrapure UTP supplied as clear aqueous solution.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Shelf Life: 12 months
Molecular Formula: C9H15N2O15P3 (free acid)
Molecular Weight: 484.14 g/mol (free acid)
CAS#: 19817-92-6
Purity: ≥ 99 % (HPLC)
Form: clear aqueous solution
Concentration: 100 mM ±2 %
pH: 8.0 ±0.2 (22 °C)
Spectroscopic Properties: λmax 262 nm, ε 9.8 L mmol-1 cm-1 (Tris-HCl pH 7.0)
Applications:
Activation of purinergic receptors[1,2,3,4]
Cardioprotection against hypoxic damage[2]
Enzyme kinetic parameters[5]
Phosphorylation of EGF-receptor vie purinergic receptors[3]
Stimulation of neurogenesis and dopaminergic neurons[6]
Specific Ligands:
Enterovirus 71 3D RNA polymerase[7]
Ligand for purinergic receptors:
P2X1[4]
P2Y2[7,8,9,10]
P2Y4[8,10,11]
P2Y6[8]
Selected References:
[1] Raqeeb et al. (2011) Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium 49:240.
[2] Golan et al. (2011) Extracellular nucleotide derivatives protect cardiomyocytes against hypoxic stress. Biochemical Pharmacology 81:1219.
[3] Boucher et al. (2011) Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. American Journal Pathology 178:1092.
[4] Sugihara et al. (2011) Dual signaling pathway of arterial constriction by extracellular uridine-5-triphosphate in the rat. J. Pharmacological Sciences (Japan) 115:293.
[5] Ma et al. (2011) Molecular cloning and analysis of the UDP-glucose pyrophosphorylase in Streptococcus equi subsp. Zooepidemicus. Molecular Biology Reports 38:2751.
[6] Delic et al. (2011) Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Puronergic Signalling 6:417.
[7] Jiang et al. (2011) Biochemical characterization of enterovirus 71 3D RNA polymerase. Biochim. Biophys. Acta, Gene Regulatory Mechanisms 1809:211.
[8] Pendergast et al. (2001) Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. 11 (2):157.
[9] Shaver et al. (1997) 4-substituted uridine 5'-triphosphates as agonists of the P2Y2 purinergic receptor. Nucleosides and Nucleotides 16 (7):1099.
[10] Kim et al. (2002) Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4 and P2Y11 but not P2Y6 receptors. J. Med. Chem. 45:208.
[11] Nguyen et al. (1995) Cloning, expression, and chromosomal localization of human uridine nucleotide receptors. J. Biol. Chem. 270 (52):30845.
| Cat. No. | Amount | Price |
|---|---|---|
| NU-1013 | 1 ml (100 mM) | 52,30 € |
| NU-1013-100ML | 100 ml (100 mM) | Ask for Quotation |
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Scientific citations for Jena Bioscience nu-1013-sol
10 scientific citations and 0 citation images found by Bioz.
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Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement.
Cell, 2025-06-25 · PMID:40580950
.. ..15-140-122 Poly-L-arginine Sigma-Aldrich Cat#P7762 Pseudouridine Sigma-Aldrich Cat# SMB00912
Pseudo-UTP solution 100 mMJena Bioscience Cat#NU-1139S Recombinant Human IL-3 MPI of Biochemistry,.. .. -
Y-switch: a spring-loaded synthetic gene switch for robust DNA/RNA signal amplification and detection.
Nucleic Acids Research, 2024-08-16 · PMID:39149901
.. ladders (Cat. #SM1211 & #SM0311), DNA loading dye (Cat. #R0611) from Thermo Fischer Scientific.. ATP (Cat. #NU-1010), GTP (Cat. #NU-1012), CTP (Cat. #NU-1011), and UTP (Cat. #
NU-1013 Jena Bioscience .. RNA loading dye (Cat. #B0363S), T7 RNA polymerase (Cat. #M0251), ssRNA ladder (Cat. #N0364), .. -
In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024-06-05 · PMID:38491873
For synthesis of nucleotide-modified mRNA,
unmodified uridine triphosphate was fully replaced with chemically modified nucleotides (Ψ, m1Ψ, 5moU; 100 mM; allJena Bioscience , Germany). mRNA integrity was verified by running 2 uL of mRNA with 5 uL loading dye (included in the IVT kit) on a 0.9% RNAse-free agarose gel. mRNA concentration was adjusted to 1 mg mL−1 using UV–vis-spectroscopy (NanoDrop 1000; Peqlab, Erlangen, Germany).
