Tenofovir-DP, Sodium salt
[2-(6-Amno-9H-purin-9-yl)-1-methylethoxy]methyl-triphosphate; [(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphinic acid
For research use only!
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H16N5O10P3 (free acid)
Molecular Weight: 447.17 g/mol (free acid)
Exact Mass: 447.01 g/mol (free acid)
Purity: ≥ 95 % (HPLC)
Color: white to off-white
Spectroscopic Properties: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Zheng et al. (2016) Application of an intracellular assay for determination of Tenofovir-diphosphate and Emtricitabine-triphosphate from erythrocytes using Dried Blood Spots. J. Pharm. Biomed. Anal. 122:16.
Dickinson et al. (2015) Plasma Tenofovir, Emtricitabine, and Rilpivirine and Intracellular Tenofovir Diphosphate and Emtricitabine Triphosphate Pharmacokinetics following Drug Intake Cessation. Antimicrob. Agents Chemother. 59 (10):6080.