dCpNHpp
![Structural formula of dCpNHpp ((dCMPNPP), 2'-Deoxycytidine-5'-[(α,β)-imido]triphosphate, Sodium salt)](/image/ViewImageFit:1731x1299://images/Structures/NU-439.png "product dCpNHpp (dCPNPP)")
For research use only.
Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life: 12 months after date of delivery
Molecular Formula: C9H17N4O12P3 (free acid)
Molecular Weight: 466.17 g/mol (free acid)
Exact Mass: 466.01 g/mol (free acid)
CAS#: 791761-70-1 (free acid)
Purity: ≥ 95 % (HPLC)
Form: solid
Color: white to off-white
Spectroscopic Properties: λmax 271 nm, ε 9.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Selected References:
Moscato et al. (2016) Induced Fit in the Selection of Correct versus Incorrect Nucleotides by DNA Polymerase β. Biochemistry 55 (2):382.
Patra et al. (2015) Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV. J. Am. Chem. Soc. 137 (22):7011.
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Scientific citations for Jena Bioscience nu-439
5 scientific citations and 3 citation images found by Bioz.
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Continuous assay for the dNTP triphosphohydrolase of activated SAMHD1.
Analytical biochemistry, 2025-10-30 · PMID:40902696
Abstract: Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is the only member of the triphosphoric monoester hydrolase family in humans (dNTP + H 2 O → dN + PPPi). The dNTPase activity of SAMHD1 inhibits DNA synthesis, resulting in cell-cycle arrest and restricting viral replication. The complex allosteric regulation mechanism of SAMHD1 and a reaction that lacks a direct spectroscopic signal make its kinetic analysis and inhibitor discovery challenging
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Replication Bypass of the N -(2-Deoxy- d -erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η
Biochemistry, 2024-02-27 · PMID:38413007
-5′-[(α,β)-imido]triphosphate (sodium salt; dCMPnPP), 2′-deoxyguanosine-5′-[(α,β)-imido]triphosphate (sodium salt; dGMPnPP), and 2′-deoxythymidine-5′-[(α,β)-imido]triphosphate (sodium salt; dTMPnPP) (
Jena Bio -
A polar filter in DNA polymerases prevents ribonucleotide incorporation
Nucleic Acids Research, 2019-11-18 · PMID:31544946
.. in water and annealed.The purified oligonucleotide was desalted, lyophilized, solubilized in water and annealed.. The ternary complexes were reconstituted by mixing MsDpo4 (0.3 mM) with annealed dsDNA in a molar ratio of 1:1.2 followed by addition of
5 mM dCpNHpp or CpCpp (Jena Bioscience ) and MgCl 2 or MnCl 2 , respectively.. Crystallization trials were carried out by the hanging drop method using commercial screens.Crystallization trials ..
